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Hemato > Linfoma Do Manto > Flashcards

Linfoma Do Manto Flashcards

1
Q

Imunofenotipagem do linfoma do manto

A

CD20+, CD5+, CD10-, ciclina D1+
CD23-, CD200-

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2
Q

Quais são os subtipos citológicos do linfoma do manto?

A

Clássico
Blastoide
Pleomorfica

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3
Q

Como se encontra o sox11 nos subtipos clássico e blastoide?

A

Clássico: sox11 +
Blastoide (ou variante leucemica): sox11 -

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4
Q

Qual marcador de imunohistoquimica pode ser usado para diferenciar LLC de linfoma do manto?

A

LLC LEF1 +
Manto LEF1 -

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5
Q

Qual CD vem positivo no manto e LLC?

A

CD5+

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6
Q

Como diferencia manto de LLC na imunofeno?

A

Manto CD20+, CD200-, CD23-, ciclina D1 + e SOX11 +
LLC. CD20+ fraco, CD23+, CD200+,

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7
Q

Qual é o escore de prognóstico do linfoma do manto?

A

MIPI

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8
Q

Quais são os critérios do MIPI (escore do linfoma do manto)?

A

Idade
PS
LDH
WBC

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9
Q

Qual a translocação típica do manto?

A

t(11,14)

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10
Q

Mutação típica LLC

A

Del11q, del17p, del13q, trissomia 12

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Hemato (2 decks)

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