Ligand gated ion channels as drug targets Flashcards
1
Q
What is the structure of nicotinic ach receptors?
A
pentameric structure
(five subunits
each subunit has 4 membranes spanning helices
2
Q
where are nAchR found?
A
NMJ, autonomic ganglia and the CNS
3
Q
what is the structure of N-methyl-D-aspartate receptor?
A
NMdA is an ionotropic receptor… tetrameric made of 7 different types of subunits
4
Q
What region of a nuclear receptor facilitates translocation from the cytoplasm into the nucleus?
A
Hinge region
it facilitates dimerisation, and hence translocation of the receptor, into the nucleus
5
Q
What is the function of dimerization in kinase-linked receptors?
A
It enables a mutual autophosphorylation of tyrosine residues by tyrosine kinase
