Lifestyle and Influence - Topic 1 Flashcards

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1
Q

What is diffusion?

A

Diffusion is the net movement of particles from an area of high concentration to an area of low concentration. Particles are always moving and net movement is the sum of all movement of particles. In diffusion, particles move down a concentration gradient.

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2
Q

Describe the flow of blood through the heart

A

Great veins receive deoxygenated blood from the body, the superior vena cava brings deoxygenated blood from the heads and arms and the inferior vena cava brings blood from the rest of the lower body.
Blood enters the right atrium from the vena cava at relatively low pressure and once pressure builds up in the atrium then the atrioventricular valve (tricuspid valve) opens up.
Blood enters the ventricle following the contraction of the atrium.

Blood re-enters the heart through the pulmonary veins at low pressure due to the long capillary journey. The atrium fills with blood first and contracts which forces blood through the atrioventricular valve which causes blood to enter the ventricle. The contraction of the ventricle provides sufficient force to move and take the blood to all of the body extremities via the aorta.

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3
Q

What do valves do?

A

Valves prevent the back flow of blood. Valves allow the unidirectional flow as tendinous cords stop inverting under high pressure.

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4
Q

Why is the left ventricle wall thicker than the right ventricle?

A

The left ventricle wall is thicker than the right ventricle wall because the left side of the heart has to pump blood around he body to all of the body extremities, whereas the right side of the heart only has to pump blood to the lungs

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5
Q

Describe the structure of an artery

A

“Arteries have thick walls made up of collagen and elastic fibres, collagen is a tough fibrous protein, this makes the artery walls strong and durable. The arteries need such thick walls in order to withstand the high pressure of the blood as it enters from the heart when it contracts (systole) and is forced against the walls.
Due to the thick walls of arteries, the lumen is very narrow.
The heart has a large effect on the flow of blood in the arteries, blood flows at high pressure with constant pulses due to systole.
Smooth muscle surrounds the lumen to allow the flow of blood at such a high pressure to be as efficient as possible.
During diastole (relaxation of the heart), the elastic fibres of the artery walls causes them to recoil behind the blood, this helps to push the blood forward.
There are no valves in the arteries.”

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6
Q

Describe the structure of a vein

A

“The vein wall is also made up of collagen and elastic fibres but there are much less of them, this is because blood in veins is under relatively low pressure and the flow of blood is more continuous
As a result of thinner walls, veins have a much larger lumen which helps in the assist of blood flow return to the heart.
Smooth muscle surrounds the lumen to allow the flow of blood to be as efficient as possible
The flow of blood in veins is assisted by the contraction of skeletal muscles during the movement of limbs and breathing. The skeletal muscles contract which push blood forwards, it’s the valves that prevent the backward flow of blood by closing.
The heart has little effect on the flow of blood in the veins, where it flows steadily and without pulses.”

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7
Q

Describe the structure of a capillary

A

“By the time blood reaches the capillaries there is already a steady flow of blood (low pressure).
Blood flows through capillaries relatively slowly, this is due to the very narrow lumen. The flow of blood is slowed down due to friction with the wall of the capillary.
The slow flow of blood allows exchange of materials between the blood and surrounding cells though the endothelium (one-cell thick wall).

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8
Q

Why is water a polar molecule?

A

Water (H20) has an unevenly distributed electrical charge, the hydrogen end of the molecule is slightly positive whilst the oxygen end of the molecule is slightly negative. This is because the electrons are more concentrated to that end. WATER IS A DIPOLE (electrically neutral molecule)

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9
Q

Water molecules

A

The slightly positive charged end of a water molecule is attracted to the slightly negative ends of surrounding water molecules - hydrogen bonds old the water molecules together and results in many of waters properties including being a liquid at room temperature.

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10
Q

POLAR MOLECULES

A

Polar molecules dissolve in water because they’re hydrophilic (water loving), they become surrounded by water and go into solution.

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11
Q

NON-POLAR MOLECULES

A

Non-polar molecules such as lipids (fats) don’t dissolve in water because they have both a non polar end and polar end, meaning one end of a lipid is hydrophilic and the other end is hydrophobic. to be able to dissolve in water, lipids need to combine with proteins to form lipoproteins.

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12
Q

Ionic substances in water

A

Sodium chloride dissolves easily in water, this is because the negative Chlorine ions are attracted to the positive ends of the water molecules and the positive sodium ions are attracted to the negative ends of the water molecule. The chlorine and sodium ions become hydrated in an aqueous solution and become surrounded by the water molecules.

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13
Q

Why is the amount of energy required to raise the temperature of water very high?

A

It takes a lot of energy to increase the temperature of water because in order to do this you have to break the hydrogen bonds which takes a lot of energy to do this. A large input of energy causes only a small increase in temperature. Therefore water also has a high boiling point

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14
Q

LOOK AT BLOOD IN NOTES

A

LOOK IN NOTES

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15
Q

ATRIAL SYSTOLE (CONTRACTION)

A

Blood re-enters the heart due to the movement of skeletal muscles and stuff. Blood under low pressure flows into the atria from the vena cava and pulmonary veins. As the atria fill, the increasing pressure in the atria causes the atrioventricular valves to open and blood flows into the ventricles. The atria walls then contract simultaneously forcing any remaining blood into the ventricles.

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16
Q

VENTRICULAR SYSTOLE (CONTRACTION)

A

After a slight delay, atrial systole is followed by ventricular systole. The ventricles contract form the base of the heart upwards, increasing the pressure in the ventricles which forces the semi lunar valves to open - the blood is pushed up and out of the pulmonary arteries and aorta. The pressure of blood against the atrioventricular valves causes them to close and prevents blood from flowing backwards (creates the first heart sound - ‘lub’ ).

17
Q

CARDIAC DIASTOLE (RELAXATION)

A

The atria and ventricles relax during cardiac diastole. Elastic recoil of the relaxing heart walls lowers the pressure in the atria and ventricles. Blood under higher pressure in the pulmonary arteries and aorta is drawn back towards the ventricles which closes the semi lunar valves (DUB) and prevents the back flow of blood into the ventricles. The coronary arteries fill during diastole and the low pressure in the atria helps to draw blood into the heart from the veins (vena cava and the pulmonary veins).

18
Q

BLOOD CLOTTS

A

Blood clots are a resulting factor of a tear/damage to the endothelBlood clots are a resulting factor of a tear/damage to the endotheliuiuf larger cells) come into contact with the damaged vessel they change from their flattened disc shape into spheres with projections which makes them stick together (sticky). This causes them to stick together and to the damaged vessel causing a temporary plug. The platelets and damaged vessels release a protein called THROMBOPLASTIN. The thromboplastin reacts with the calcium and vitamin k found in the plasma of the blood to catalyse the conversion of the protein PROTHROMBIN into the enzyme THROMBIN. Thrombin then catalyses the conversion of the soluble plasma protein FIBRINOGEN into the insoluble protein fibrin. A fibrin mesh forms, this traps more platelets and red blood cells to form a clot. Once the damaged has been healed the clot is dissolved by the blood.

19
Q

ATHEROSCLEROSIS

A

Atherosclerosis starts off with damage being caused to the endothelium. The endothelium damage can result from high blood pressure which puts extra strain on the layer of cells. Once the inner lining of the artery is breached, there is an INFLAMMATORY RESPONSE - WBC leave the blood vessel and move into the artery wall. These cells accumulate chemicals from the blood such as CHOLESTEROL - and a fatty acid builds up (ATHEROMA). Calcium salts and fibrous tissue also build up at the site resulting in a hard swelling called plaque on the inner wall of the artery. The build up of fibrous tissue means that the wall loses some of its elasticity (hardens). Plaques cause the lumen of the artery to become narrower - more difficult for the heart to pump blood around the body and this can lead to raised blood pressure (DANGEROUS POSITIVE FEEDBACK). The raised blood pressure makes it more likely that other plaques will form as damage to endothelial tissue in other areas becomes more likely.

20
Q

RISK

A

The probability of an unwanted event or outcome

When looking at calculated risk values you need to think about the exposure to the hazard.
People will over estimate risk of something happening if the risk is;
Involuntary
Not natural
Unfamiliar 
Dreaded 
Unfair
Very small

There

21
Q

PROBABILITY

A

Has a precise mathematical meaning and can be given a numerical value or percentage

22
Q

Consequences of Atherosclerosis

A

CORONARY HEART DISEASE
The narrowing of arteries limits the amount of oxygen rich blood reaching the heart muscle. This may result in ANGINA - usually experienced during exertion when cardiac muscles are working harder & need to respire more and because the heart muscle lacks oxygen it has to respire anaerobically. If the fatty plaque in the artery ruptures, collagen is exposed which leads to rapid clot formation - which means that blood supply to the heart may be blocked completely. The heart muscle supplied by the blocked artery doesn’t receive any blood (ISCHAEMIC - without blood). If the effected muscle cells are starved of oxygen for too long then they’re permanently damaged (HEART ATTACK / MYOCARDIAL INFECTION)

STROKE
If the supply of blood to the brain is only briefly interrupted then a mini-stroke may occur. Mini-stroke has same symptoms as a full stroke - but the effects last for a shorter period, a mini-stroke is a warning of problems with blood supply to the brain that could result in a full stroke.
Blood clots blocking the arteries leading to the brain is called a FULL STROKE - The brain cells die if they’re starved of oxygen for more than a few minutes.