Li Fraumeni Syndrome Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What is the classical definition of Li-Fraumeni syndrome?

A

All of the following:

  1. A proband with a sarcoma diagnosis <45yo
  2. First degree relative with any cancer <45yo
  3. A first or second degree relative with any cancer before age 45yo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the clinical characteristics of Li-Fraumeni syndrome?

A

Cancer predisposition syndrome associated with following classic tumors:

  1. ST sarcoma
  2. Osteosarcoma
  3. Pre-menopausal breast cancer
  4. Brain tumors
  5. Adrenocortical carcinoma
  6. Leukemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What gene is associated with LFS?

A

TP53

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the inheritance pattern of LFS?

A

AD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly