LG 2.12 Pathology: Abnormalities of Bone- Osteoporosis

Question 1

What is Osteoporosis?

Answer 1

A multifactorial disease characterized by an absolute reduction of the total bone mass and is probably the most prevalent bone disease in our society.

Question 2

Is osteoporosis more common in men or women? Why

Answer 2

Women. After menopause, a. Bone resorption is accelerated in women 3-5 times, resulting in a bone loss in the range of 1-3%/ year. The reasons for this accelerated bone loss, which occurs over a period of 8-10 years are not known, but are related to estrogens. Also women, are predisposed due to their skeletal structure

Question 3

Etiology of osteoporosis

Answer 3

Unknown

Question 4

Primary osteoporosis is common in what population?

Answer 4

Elderly

Question 5

How does secondary osteoporosis vary from primary?

Answer 5

Secondary can occur at any age and related to identifiable cause. Primary occurs in elderly.

Question 6

What are possible causes of secondary osteoporosis?

Answer 6

1. Immobilization, as in chronic diseases.
2. Following Trauma
3. Tumors that metastasize and destroy the bone, as in prostate or breast cancer.
4. Hormonal disturbances.
5. Malabsorption of nutrients, such as in cirrhosis or intestinal disease.

Question 7

What are possible signs and symptoms of osteoporosis?

Answer 7

• Variable and on specific.
• Can cause vertebral fractures
• May reduce height if extensive
• Long bone fractures

Question 8

What is your diet can reduce osteoporosis?

Answer 8

Dietary Calcium and Vitamin D

Question 9

Describe the pathophysiology of osteoporosis

Answer 9

i. Characterized by the simultaneous loss of the organic bone matrix (osteoid) and minerals.
ii. Normal bones are remodeled during the entire lifespan. During the growth phase and up to approx. 30 years of age, bone formation exceeds bone resorption. After this age, bone resorption outpaces bone formation, resulting in a net bone loss of about 0.5% of the total bone mass per year

Question 10

Pathology of bones in osteoporosis.

Answer 10

Osteoporotic bones are thin and brittle, and are prone to fracture. This bone loss involves both the cortical and spongy bone.

Question 11

What occurs in the bones of post menapausal women, pathologically?

Answer 11

In osteoporosis involving postmenopausal women, trabecular bone loss predominates, occurring in the vertebrae and distal radius.