LFTs Flashcards
Aasparate aminotransferase AST
dont usually come with LFT request
AST:ALT ratio very helpful.
Can lead to cause
Alanine glutamyl-transferase ALT
very important and very specific. elevated most likely shows hepatic damage
acute hepatic LFTs picture
ALT/AST in 1000s
ALP mildly raised
Chronic hepatic LFTs picture
ALT/AST 100s
Albumin reduced or normal
Cholestatic (obstructive) picture
ALP up to 1000s
ALT/AST mildly raised or normal
Increased bilirubin
Alcoholics
Increased Gamma glutamyl transferase
increased MCV
Alkalaine Phosphate AlkPh
from billary ducts and bones (pagets)
If in CKD increased then could mean renal osteodystrophy
How to approach AST interpretation
Look how much is it multiplied from normal.
commonest cause is AST:ALT ratio >2.5x with ALT not changes. this shows alcoholic cirrhosis
Paracetamol overdose AST
will show 2-5x from normal
AST:ALT = 1
ischaemia, CCF, MI, necrosis and hepatitis
AST:ALT >2.5
associated with alcoholic cirrhosis, often patients deny alcohol
AST:ALT <1
Paracetamol OD, viral hepatitis, toxic hepatitis
what LFT results show a hepatitic picture
When ALT elevated but ALP and Bilirubin normal
What LFT results show cholestatic picture
When ALP and bilirubin elevated but ALT normal
categories of cholestatic picture
obstructive or non–obstrutive
