LFTs

Question 1

What liver enzymes are found on the membrane?

Answer 1

ALP & GGT

Question 2

Which liver enzymes are found in the cytoplasm?

Answer 2

AST, ALP & LD

Question 3

Which liver enzyme is found in both the cytoplasm & mitochondria?

Answer 3

AST

Question 4

Which liver enzymes are found in other tissues?

Answer 4

AST - bone & muscles
ALP - bone & placenta
GGT - biliary epithelium & kidney

Question 5

What enzyme changes are seen in liver necrosis (i.e. toxin & virus?

Answer 5

Cell damage leading to release of LD, AST & ALP

AST particularly elevated with toxin

Question 6

What enzyme changes are seen in biliary disease?

Answer 6

Cell stress (biliary epithelium) & bile dissolves membranes
Release of membrane enzymes GGT & ALT

Question 7

What LFTs reflect intra & extra-heptatic jaundice?

Answer 7

Intrahepatic - some elevation of GGT & ALT

Extra - marked elevation (10x) of GGT & ALT

Question 8

What LFT results reflect chronic/resolving injury?

Answer 8

ALT > AST

Question 9

What LFT results reflect acute injury?

Answer 9

AST > ALT

Question 10

What enzyme is predominantly elevated in acute hepatitis?

Answer 10

ALT - marked elevation, much higher than in chronic hepatitis