LFTs Flashcards
What does a raised AST, ALP, GGT indicate?
damage to the liver
What does raised bilirubin, albumin, prothrombin indicate?
livers ability to conjugate & synthesis protein
What does a raised ALT or AST mean?
if raised, damage by disease process (hepatocellular damage)
What does a raised ALP & GGT indicate?
cholestatic damage (flow of bile, carries bilirubin from liver to SI)
Where is ALT found mainly?
liver parenchymal cells
Where is AST found?
liver parenchymal cells, myocardium, skeletal muscle, kidney & brain
Is ALT or AST more specific to liver damage?
ALT
What does ALT>AST mean
associated with most liver disease
What does AST>ALT mean?
associated with cirrhosis and acute alcoholic hepatitis (or non-liver cause)
What are the causes of raised ALT/AST?
- Alcoholic fatty liver disease
- Non-alcoholic fatty liver disease
- Viral hepatitis
- Drug toxicity
- Autoimmune hepatitis
- Liver cirrhosis
Where is ALP found?
found in bile duct & bone
Where is GGT found?
found in bile duct cells (more specific to cholestatic damage)
What does >10-fold increase in ALT with <3-fold increase in ALP mean?
hepatocellular injury
What does only an ALP rise indicate?
bone pathology
What does <10-fold increase in ALT with <3-fold increase in ALP mean?
cholestasis
