lft interpretation Flashcards
what is seen in acute hepatitis ?
ALT/AST in 1000s
mild ALP
in chronic hepatitis?
ALT/AST in 100s
decreased bilirubin
cholestatic picture
ALP 100S
ALT/AST mildly raised
increased Bilrubin
alcohol
decreased platelet/Hb, increased MCV and gama GT
what is specific to liver
ALT
what can AST be seen in
liver heart muscles kidney pancreas
marked increases (1000s)
drug induced hep
liver ischamea
hepatitis viral A, B E EBV CMV
modest increase
AIH
chronic
alcohol
mild increased
HCC
WILSON HAEM
NAFLD
CIRRHOSIS
ratio and cause
ALT>AST - cHRONIC LIVER DISEASE
ast/alt in establsshed cirrhosis - or in ALD
alp SEEN WHERE
SPECIFIC TO BILARY DUTS AND BONE
what can be ued to confirm source
ygt can differentiate bebtwene born and bilary cause
marked increase
PSC PBC gall stones pancreatic ca drugs 4x normal
moderate increase
hepatitis
cirrhosis
hcc
when can ygt be raised
enzyme inducing drugs
alcohol
to confirm ALP origin of disease being liver origin
wwhen albumin is low how can protein differentiate
increased with protein -myeloma
decrease protein -reduced protein intake,, alcohol, cirrhosis, skin loss etc
with normal protein=infection
what can raised INR indicate
liver disease
anticogultation
vitamin k deficiency
DIC
list cause of all markers:
anti smooth muscle anti mitochondrial anti liver kindey microsomal ant nuclear AFP
ferritin and trasnferin saturation coper and crulpaslim fasting glucose and lpids anti antitrypsin immunoglobulins igM igA igG
anti smooth muscle AIH anti mitochondrial PBC anti liver kindey microsomal - AIH hep c and d drug induced hepattis ant nuclear - AIH SLE AFP -HCC
ferritin and trasnferin saturation -haemchromatosis coper and crulpaslim -wilsons fasting glucose and lpids -nAFLD anti antitrypsin (AA defieincy) immunoglobulins igM PBC igA ALD igG - AIH
what is bilrubin
brbeak down of Hb into globulin and haem (which is broken down nto bilirubin and excreted in bile after coguaiton in liver
causes of unconjugated hyperbirubunia
increased rcc breakdown
impaired hepatic uptake
impaired conjugation glberts, jaundice neonatal
causes of conjugated
hepatocellular dysunction
impaired hepatic secretion
