LFT/bloods Flashcards
marker of synthetic function and is useful for gauging the severity of chronic liver disease
plasma protein formed by liver
serum albumin
normal is 35-50
low albumin may suggest ? (3)
Liver disease (e.g. cirrhosis).
Inflammation triggering an acute phase response which temporarily decreases the liver’s production of albumin.
Excessive loss of albumin due to protein-losing enteropathies or nephrotic syndrome.
raised serum IgG indicates
autoimmune hepatitis
raised IgM indicates
primary biliary cholangitis
a product of the breakdown of red blood cells
bilirubin
3-17 normal range
Normal urine + normal stools
pre-hepatic cause
Dark urine + normal stools
hepatic cause
Dark urine + pale stools
post-hepatic cause (obstructive)
measure of the blood’s coagulation tendency, specifically assessing the extrinsic pathway. In the absence of other secondary causes such as anticoagulant drug use and vitamin K deficiency, an increased ___ ____ can indicate liver disease and dysfunction.
prothrombin time normal range is 10-14
an enzyme of the liver released when hepatocytes die, normal range 3-30
AST - aspartate aminotransferase
an enzyme of the liver released when hepatocytes die - more specific to the liver than AST - normal range 3-30
ALT - alanine aminotransferase
raised AST indicates
hepatic necrosis, MI etc
when is ALT higher than AST
in viral hepatitis without cirrhosis
AST is often higher than ALT in
alcoholic liver disease and steatohepatitis
in patients with liver disease without cirrhosis in whom AST is greater than ALT this suggests…
alcohol or obesity is most likely aetiological cause
