Lewy Body dementia

Question 1

Lewy Body

Answer 1

• weakly eosinophilic, spherical,cytosplasmic inclusions

Question 2

Parkinsons disease

Answer 2

-lewy bodies are confined to the substantia nigra

Question 3

Dementia with lewy body

Answer 3

• lewy bodies are in the substantia nigra but they are also in the temporal lobe, cingulate gyrus and frontal lobes
• they may also be found in the dorsal motor nucleus of the vagus

Question 4

Cortical Lewy bodies

Answer 4

-less conspicious, less eosinophilic and lack clear halo compared to those in the substantia nigra

Question 5

Lewy bodies and cognitive decline

Answer 5

-there is no simple correlation between the number of Lewy bodies and cognitive decline

Question 6

How to idenitify Lewy Bodies

Answer 6

• antibody to protease ubiquitin can be used
• staining with antibody alpha-synuclein helps identify lewy bodies
• DLB is one of the various degenerative synucleopathies

Question 7

Microvacuolation

Answer 7

• some patients with DLB show microvacuolation of the cerebral cortex predominantly in the medial temporal regions
• this can mimic prion disease