Levodopa

Question 1

What contraindications should be excluded before prescribing levodopa?

Answer 1

Glaucoma

Question 2

How would you explain the MOA of levodopa to a patient?

Answer 2

• Levodopa is a replacement for some of the dopamine which your brain is no longer able to produce
• This will help to reduce your symptoms, particularly your rigidity and slow movements
• Given with carbidopa to reduce the side effects of levodopa

Question 3

How should levodopa be taken?

Answer 3

• 3-4 times daily tablet with food (reduces nausea)
• Taken as long as it works effectively - after 5 years most suffer ‘‘on-off’/wearing off (switch between mobility and immobility that occurs before the next dose is use) and dyskinesias
• Fast-acting

Question 4

What monitoring is required for levodopa?

Answer 4

None

Question 5

What are the side effects of levodopa?

Answer 5

• Psychosis
• Nausea and vomiting
• Dyskinesias
• Postural hypotension
• ‘On-off’/’wearing off’ phenomena
• Impulsive behaviour
• Dizziness