levinson questions Flashcards
160: many viruses mature by budding through the outer membrane of the host cell. each of teh following statements regarding these viruses is correct except:
A: some of these viruses cause multinucleated giant cell formation
B; some new viral antigens appear on teh surface of the host cell
C: some of the se viruses contain host cell lipids
D: some of these viruses do not have an envelope
D
184: which one of the following viruses possesses a genome of single-stranded RNA that is infectious when purified? A: influenza virus B: rotavirus C: measles virus D: poliovirus
D
A and B are ortho and paramyxovirus, so both are - ssRNA.
189: each of the following statements about both measles virus and rubella virus is correct except:
A: they are RNA enveloped viruses
B: their virions contain an RNA polymerase
C: they have a single antigenic type
D: they are transmitted by respiratory aerosol
B
223: each of the following statements about mumps is correct except:
A: mumps virus is a paramyxovirus and hence has a single-stranded RNA genome
B: meningitis is a recognized complication of mumps
C: mumps orchitis in children prior to puberty often causes sterility
D: during mumps, the virus spreads through the bloodstream (viremia) to various internal organs
C
226: the role of an infectious agent in the pathogenesis of kuru was best demonstrated by which one of the following observations?
A: a 16-fold rise in antibody titer to the agent was observed
B: the viral genome was isolated from infected neurons
C: electron micrographs of the brains of infected individuals demonstrated intracellular structures resembling paramyxo-virus nucleocapsids
D: the disease was serially transmitted to experimental animals
D
230: scrapie and kuru possess all of the following characteristics except:
A: a histologic picture of spongiform encephalopathy
B: transmissibility to animals associated with a long incubation period
C: slowly progressive deterioration of brain function
D: prominent intranuclear inclusions in oligodendrocytes
D
231: each of the following statements concerning subacute sclerosing panencephalitis is correct except:
A: immunosuppression is a frequent predisposing factor
B: aggregates of helical nucleocapsids are found in infected cells
C: high titers of measles antibody are found in CSF
D: slowly progressive deterioration of brain function occurs
A
237: which one of the following is the BEST evidence on which to base a decisive diagnosis of acute mumps disease?
A: a positive skin test
B: a four-fold rise in antibody titer to mumps antigen
C: a history of exposure to a child with mumps
D: orchitis in young adult male
B
256: each of the following statements concerning measles vaccine is correct except:
A: the vaccine contains live, attenuated virus
B: the vaccine should not be given at the same time as the mumps vaccine because the immune system cannot respond to two viral antigens given at the same time
C: virus in the vaccine contains only on serotype
D: the vaccine should not be given prior to 15 months of age because maternal antibodies can prevent an immune response
B
271: which one of the following statements concerning mumps is correct?
A: although the salivary glands are the most obvious sites of infection, the testes, ovaries and pancreas can be involved as well
B: because tehre is no vaccine against mumps, passive immunization is the only means of preventing the disease
C: the diagnosis of mumps is made on clinical grounds because the virus cannot be grown in cell culture and serologic tests are inaccurate
D: second episodes of mumps can occur because there are two serotypes of the virus and protection is type-specific
A
block 2, 32: regarding prions and prion-caused diseases, which one of the following is most accurate?
A: prions are highly resistant to both UV light and to boiling but are inactivated by hypochlorite
B: prions are protein-containing particles surrounded by lipo-protein envelope with a DNA polymerase in the envelope
C: the diagnosis of prion-caused diseases such as creutzfeldt-Jakob disease is typically made by observing cytopathic effect in cell culture
D: Creutzfeldt-Jakob disease occurs primarily in the children younger than the age of 2 years because they cannot mount an adequate immune response to the prion protein
A
252: each of the following statements is correct except:
A: coxsackie viruses are enteroviruses and can replicate in both the respiratory and GI tracts
B: influenza viruses have multiple serotypes based on hemagglutinin and neuraminidase proteins located on the envelope surface
C: flaviviruses are RNA enveloped viruses that replicate in animals as well as humans
D: adenoviruses are RNA enveloped viruses that are an important cause of STDs
D
257: each of hte following statements concerning rubella is correct except:
A: congenital abnormalities occur primarily when a pregnant woman is infected during the first trimester
B: women who say that they have never had rubella can, nevertheless, have neutralizing antibody in their serum
C: in a 6-year-old child, rubella is a mild, self-limited disease with few complications
D: acyclovir is effective in the treatment of congenital rubella syndrome
D
259: each of the following statements concerning arboviruses is correct except:
A: the pathogenesis of dengue hemorrhagic shock syndrome is associated with the heterotypic anamnestic response
B: wild birds are the reservoir for encephalitis viruses but not for yellow fever virus
C: ticks are the main mode of transmission for both encephalitis viruses and yellow fever viruses
D: there is a live, attenuated vaccine that effectively prevents yellow fever
C
270: each of the following statements concerning yellow fever is correct except:
A: yellow fever virus is transmitted by the aedes aegypti mosquito in the urban form of yellow fever
B: infection by yellow fever virus causes significant damage to hepatocytes
C: nonhuman primates in the jungle are a major reservoir of yellow fever virus
D: acyclovir is an effective treatment for yellow fever
D
select the lettered option that is most closely associated with the numbered items A: yellow fever virus B: rabies virus C: rotavirus D: rubella virus E: rhinovirus
276: diarrhea
C
select the lettered option that is most closely associated with the numbered items A: yellow fever virus B: rabies virus C: rotavirus D: rubella virus E: rhinovirus
277: jaundice
A
select the lettered option that is most closely associated with the numbered items A: yellow fever virus B: rabies virus C: rotavirus D: rubella virus E: rhinovirus
278: congenital abnormalities
D
select the lettered option that is most closely associated with the numbered items A: yellow fever virus B: rabies virus C: rotavirus D: rubella virus E: rhinovirus
279: encephalitis
B
block 1, 39: regarding parvovirus B19, which one of the following is most accurate?
A: parvovirus B19 has a double-stranded DNA genome but requires a DNA polymerase in the virion because it replicates in the cytoplasm
B: parvovirus B19 is transmitted primarily by sexual intercourse
C: parvovirus B19 causes severe anemia because it preferentially infects erythrocyte precursors
D: patients infected by parvovirus B19 can be diagnosed in the laboratory using the cold agglutinin test
E: patients with the disseminated disease caused by parvovirus B19 should be treated with acyclovir
C
clinical case 41: a 6-year-old girl has a rash on her face that appeared yesterday. the rash is erythematous and located over the malar eminences bilaterally. the rash is macular; there are no papules, vesicles or pustules. a few days prior to the appearance of the rash, she had a runny nose and anorexia
what is the diagnosis?
diagnosis: slapped cheek syndrom caused by parvovirus B19. this virus also causes aplastic anemia becuase it preferentially infects and kills erythroblasts. it also infects the fetus, causing hyrops fetalis, and causes an immune complex-mediated arthritis, especially in adult women
162: latency is an outcome particularly characteristic of which one of the following virus groups? A: polioviruses B: herpesviruses C: rhinoviruses D: influenza viruses
B
176: which one of the following is the best explaination for the selective action of acyclovir (acycloguanosine) in herpes simplex virus (HSV)-infected cells?
A: acyclovir binds specifically to viral receptors only on the surface of the HSV-infected cells
B: Acyclovir is phosphorylated by a virus-encoded phosphokinase only within HSV-infected cells
C: Acyclovir selectively inhibits the RNA polymerase in the HSV virion
D: Acyclovir specifically blocks the matrix protein of HSV, thereby preventing release of progeny of HSV
B
187: each of the following viruses possesses double-stranded nucleic acid as its genome except: A: coxsackie virus B: herpes simplex virus C: rotavirus D: adenovirus
A
Select the one lettered option that is most closely associated with the numbered letters: A: DNA enveloped virus B: DNA nonenveloped virus C: RNA enveloped virus D: RNA nonenveloped virus
193: herpes simplex virus
A
Select the one lettered option that is most closely associated with the numbered letters: A: attachement and penetration of virion B: viral mRNA synthesis C: viral protein synthesis D: viral genome DNA synthesis E: assembly and release of progeny virus
197: main site of action of acyclovir
D