Levemir

Question 1

What did the King study compare?

Answer 1

Once daily dosing with Levemir compared to once daily dosing of Lantus.

Question 2

In the King study, what was the study method?

Answer 2

crossover design

Question 3

Describe the King study, from setup to methods to details.

Answer 3

• type 2 patients previously treated with other antihyperglycemic agents
• plasma glucose measured by CGM
• Insulin dose was adjusted daily to achieve a target of 70-120 mg/dL
• CGM data for an entire 24 hour period was measured on the second consecutive day after achieving targeted plasma glucose levels

Question 4

Describe the King study setup in detail.

Answer 4

• Subjects had been treated with other antihyperglycemic agents (prior bolus insulin therapy was not permitted)
• glucose levels monitored with Medtronic CGM
• Last meal of the day was started at 6pm
• insulin was injected at 8pm
• insulin dose was titrated to achieve target glucose of 70-120 mg/dL
• once 2 consecutive days of target glucose levels were achieved, the insulin treatment was switched to the other basal insulin and the process was repeated

Question 5

What was the primary result of the King study?

Answer 5

Levemir and Lantus are considered to be bioequivalent for 24 hour glucose as measured by CGM.