LEUKOPOIESIS Flashcards
AKA white blood cells; it is the nucleated cells that function in body defense
Leukocytes
Refers to production, development, and maturation of WBC
Leukopoiesis
What are the three major categories of Leukopoiesis?
Granulopoiesis, Monopoiesis, and Lymphopoiesis
WBC with visible granules present in the cytoplasm
Granulocytes
Granulocytes includes what? (Give the three)
Neutrophils
Eosinophils
Basophils
It have similar stages of development and are often discussed as a group
Granulocytes
Give the two growth factors of granulocytes
Granulocyte-Macrophage Colony-Stimulating-Factor (GM-CSF)
Granulocyte Colony-Stimulating-Factor (GCSF)
GM-CSF stands for?
Granulocyte-Macrophage Colony-Stimulating-Factor
GCSF stands for?
Granulocyte Colony-Stimulating-Factor
Give the stages of development of granulocytes
CFU-GEMM
Myeloblast
Promyelocyte
Myelocyte
Metamyelocytes
Band/stab/staff
Neutrophils, Eosinophils, Basophils
GIVE THE CRITERIAS FOR IDENTIFICATION OF GRANULOCYTE
PRECURSORS
- Nuclear chromatin becomes more condensed
- Nucleoli disappear
- Abundant basophilic cytoplasm with nonspecific
granulation progresses to more scant cytoplasm containing
specific granules - The nucleus indents and becomes segmented
- Overall cell size decreases
1-2% of nucleated cells in the bone marrow
MYELOBLAST
Earliest recognizable granulocytic precursor using light
microscope
MYELOBLAST
15-20 um
MYELOBLAST
Cytoplasm: Basophilic
Presence of Primary granules
MYELOBLAST
