Leukocyte Review of Development, Function and Analysis

Question 1

What are groups of progenitor cells of WBCs called?

Answer 1

Colony Forming Units (CFU)

Question 2

What are the 2 types of WBC progenitor cells?

Answer 2

Common myeloid progenitor
Common lymphoid progenitor

Question 3

What are the LMW soluble proteins that stimulate or inhibit differentiation, movement, growth, and production of leukocytes called?

Answer 3

Cytokines

Question 4

What kinds of cells are cytokines produced by?

Answer 4

Leukocytes and non-hematological cells

Question 5

How are Colony-Stimulating Factors (CSF) involved in the control of hematopoiesis?

Answer 5

They promote division and differentiation

Question 6

What kinds of proteins do interleukins interact with in the control of hematopoiesis?

Answer 6

Cytokines

Question 7

Where do neutrophils develop and mature?

Answer 7

In pools in the bone marrow

Question 8

With what kind of WBC do neutrophils share a common progenitor with? What is the progenitor called?

Answer 8

Monocytes
Granulocyte-monocyte progenitor (GMP)

Question 9

What is major cytokine responsible for the stimulation of neutrophil production called?

Answer 9

Granulocyte colony-stimulating factor (G-CSF)

Question 10

Which neutrophil stages are present in the proliferating pool of the bone marrow?

Answer 10

Myeloblast, promyelocyte, and myelocyte