Leukocyte Kinetics Flashcards
Neutrophils
Proliferate and nature in the bone marrow
There are two pools you have your circulating and marginal
Defense against bacteria
1:1
1:3 in cats (marginal higher)
Eosinophils
Bm mature and proliferate
Subepithelial areas - skin,lungs, git, endometrium
Eosinophilia
Parasitism (demodex) Hypersensitivity (format cell Malignant lymphoma Eosinophilic leukemia Hypoadrencorticism
Monocytes
No bm storage
Stored in tissues
Phagocytosis- aged tissues, fungal and viral and inflammation
They appearvbwfore neutrophils (parvo)
Lymphocytes
2ndary lymphoid tissue Thymus and spleen Long life span Humoral b cells And cellular t cells Predominant WBC in Bovines
leukocytes
Move slower in capillary bed
Adhesion molecules larger sizes when blood flow decreases they sequestration
When blood flow increases wash our effect
Effect of epinephrine of leukocytes
Fear ,excitement and excercise
Last 20-30min
Neutropholia( without left shift has a pseudoneutrophilia)
Mobilization of MNP with redistribution of CNP
Neutrophils in circulation unchanged
Lymphocytosis
Cats nb
Epinephrine actually blocks receptors in the post capillary venules
Lymphocytes can’t enter back into lymph node
Epinephrine causes release of ln in unknown source
Monocytes basophil and eosinophils unaffected
Effect of cortisol on leukocytes
Pseudoneutrophilia why
Decreased movement on tissue therefore stays in blood
Increase bm release of cells
MNP AND CNP shift
Cortisol on lymphocytes
Decreasesld
Lymphopaenia
Remain in lymphoid tissue and bm
Long term corticosteroid cause lysine of lymphocytes in cortex of thymus
Eosinopaenia in stress response why
mamarination and sequestration in tissues
Bm does not release them
Neutrophils left and right shifts
Left-increasin in immature neutrophils
In blood
Right - infrwas in hypersegment mature neutrophils in blood
Cortisol related
Leukemoid response
WBC 50000
Due to granular cells , severe inflammation IMHA
Neutrophils
Causes of neutrophilia
Physiological- excercise Corticosteroids - endo exogenous Inflammation Tissue necrosis and ischemia Tumors and leukemias
Neutropenia classifications
Margination increase adhesions due to endotoxins or slow bf decreased cells on circulations
Increased demand or destruction - inflammation rate of emigration is greater than supply
Decreased production -cytotoxic drugs, anemia aplastic,cyclic neutropenia in collies
Excessive ineffective granulopoeisis
Lymphocytes ate constantly circulated , explain the flow
Lnn - lymphocytes produced here then go to lymphatic then go to thoracic duct and then go to blood vessles where they are constantly circulated
