Leukemias Flashcards
What subgroups under AML have the ff clinical features: Tissue infiltrates; involvement of CNS?
M4 and M5
Cytochemical stains of M1, M2, M3
Sudan black B, Peroxidase, Naphthol ASD choracetate esterase
Leukemic cells outgrow normal WBC in bone marrow
Infection
Leukemic cells outgrow normal RBC in bone
marrow
Anemia
Leukemic cells outgrow megakaryocytes in the
Bone marrow
Bleeding
M2 Cytogenetic abnormality
T(8q-;21q+)
M3 Cytogenetic Abnormality
T(15; 17)
PTT and PT result of M3
Prolonged
M3 Clinical Feature
DIC
M4 Cytogenetic Abnormality
Chromosome
16 (M4e)
M5 Cytogenetic Abn
T(9; 11) (M5a)
Subgroups of AML w/ increased lysozymes
M4 and M5
M7 Cytogenetic Abn
Chromosome 21
FAB
French American British
This classification of AML is based on morphology and cytochemistry
French American British
This classification of AML relies heavily on cytogenetics and molecular characterization
WHO
____ of all nucleated cells in the bone marrow are myeloblasts according to FAB classification.
> 30%
____ of all nucleated cells in the bone marrow are myeloblasts according to WHO classification.
> 20%
What cell is stained by A-naphthyl acetate esterase and A-naphthyl butyrate esterase
Monocytic
Cytochemical stains for myeloid
Peroxidases, Sudan Black B,
Naphthol ASD chloroacetate (SuPer Nap)
Cytochem stain for monocytic
A-naphthyl acetate esterase
A-naphthyl butyrate esterase
The blasts in AML with minimal differentiation are ____
CD131, CD331, CD341, and
CD1171
CD that is present in M0
CD34
Acute myelogenous leukemia without maturation
M1
