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Hematology 2 Finals > Leukemias > Flashcards

Leukemias Flashcards

1
Q

What subgroups under AML have the ff clinical features: Tissue infiltrates; involvement of CNS?

A

M4 and M5

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2
Q

Cytochemical stains of M1, M2, M3

A

Sudan black B, Peroxidase, Naphthol ASD choracetate esterase

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3
Q

Leukemic cells outgrow normal WBC in bone marrow

A

Infection

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4
Q

Leukemic cells outgrow normal RBC in bone
marrow

A

Anemia

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5
Q

Leukemic cells outgrow megakaryocytes in the
Bone marrow

A

Bleeding

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6
Q

M2 Cytogenetic abnormality

A

T(8q-;21q+)

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7
Q

M3 Cytogenetic Abnormality

A

T(15; 17)

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8
Q

PTT and PT result of M3

A

Prolonged

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9
Q

M3 Clinical Feature

A

DIC

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10
Q

M4 Cytogenetic Abnormality

A

Chromosome
16 (M4e)

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11
Q

M5 Cytogenetic Abn

A

T(9; 11) (M5a)

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12
Q

Subgroups of AML w/ increased lysozymes

A

M4 and M5

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13
Q

M7 Cytogenetic Abn

A

Chromosome 21

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14
Q

FAB

A

French American British

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15
Q

This classification of AML is based on morphology and cytochemistry

A

French American British

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16
Q

This classification of AML relies heavily on cytogenetics and molecular characterization

A

WHO

17
Q

____ of all nucleated cells in the bone marrow are myeloblasts according to FAB classification.

A

> 30%

18
Q

____ of all nucleated cells in the bone marrow are myeloblasts according to WHO classification.

A

> 20%

19
Q

What cell is stained by A-naphthyl acetate esterase and A-naphthyl butyrate esterase

A

Monocytic

20
Q

Cytochemical stains for myeloid

A

Peroxidases, Sudan Black B,
Naphthol ASD chloroacetate (SuPer Nap)

21
Q

Cytochem stain for monocytic

A

A-naphthyl acetate esterase
A-naphthyl butyrate esterase

22
Q

The blasts in AML with minimal differentiation are ____

A

CD131, CD331, CD341, and
CD1171

23
Q

CD that is present in M0

A

CD34

24
Q

Acute myelogenous leukemia without maturation

A

M1

25
Q

Acute myelogenous leukemia with minimal differentiation

A

M0

Hematology 2 Finals (1 decks)

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