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Heme Onc Path > Leukemia lymphoma > Flashcards

Leukemia lymphoma Flashcards

1
Q

leukemia in child

A

ALL

Langerhans cell histiocytosis

Burkitt lymphoma (bimodal)

Hodgkins lymphoma (bimodal)

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2
Q

difference between leukemia reaction and CML

A

leukemoid reaction:
- incr WBC with left shift and INCREASED ALP

CML
- incr WBC with left shift and DECREASED ALP

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3
Q

low grade fever, night sweats, weight loss

A

B symptoms common in Hodgkins lymphoma

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4
Q

young child with pelvic and abdominal lesions

  • dx
  • translocation
  • histology
  • viral association
A

Burkitt lymphoma
t(8;14) - c-myc (8) and Ig heavy chain (14)
starry sky appearance (sheets of lymphocytes with interspersed macrophages)
EBV

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5
Q

CD5+

  • dx
  • translocation
A

mantle cell lymphoma

t(11;14) cyclin D1 (11) and Ig heavy chain (14)

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6
Q

painless waxing and waning lymphadenopathy

  • dx
  • translocation
A

follicular lymphoma

t(14;18) – Ig heavy chain (14), bcl-2 (18) which inhibits apoptosis

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7
Q

cutaneous patches/plaques/tumors

  • dx
  • can spread where
  • tumor marker
A

mycosis fungoides / sezary syndrome (blood form)
can spread to lymph nodes and viscera
CD4+

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8
Q

hypercalcemia, renal insufficiency, anemia, bone lytic lesions and back pain

  • dx
  • associations
  • histo
  • tx
A

multiple myeloma / plasma cell myeloma
assoc w/
- incr susceptibility to infection
- primary amyloidosis (AL)
- punched out lytic bone lesions on x ray
- M spike on SPEP
- Ig light chains in urine (Bence Jones protein)
- Rouleaux formation (RBCs stacked like poker chips in blood smear)

histo: fried egg appearance, plasma cells with clock face chromatin and intracytoplasmic inclusions w/ Ig

Bortezomib (proteasome inhibitor)

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9
Q

Down syndrome associated with

A

ALL

AML

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10
Q

CD10+

A

ALL

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11
Q

CD5+, CD20+

A

SLL/CLL

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12
Q

smudge cells in peripheral smear

A

SLL/CLL

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13
Q

Tdt+

A

ALL

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14
Q

child with mediastinal mass

  • dx
  • peripheral smear shows
  • markers
  • mets
  • what translocation has better prognosis
A

ALL

  • increased lymphoblasts
  • CD10+, Tdt+
  • CNS and testes
  • t(12;21)
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15
Q

SLL and CLL is a neoplasm of what cell

A

B cell

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16
Q

TRAP+, causes bone marrow fibrosis

  • dx
  • what cell
  • tx and mechanism
A

hairy cell leukemia
B cell
cladribine (2-CDA), an adenosine analog / antimetabolite (acts on S phase)

17
Q

Auer rods

  • dx
  • risk factors
A 
AML
alkylating chemotherapy
radiation
myeloproliferative disorders
Down syndrome
18
Q

DIC

  • dx
  • translocation
  • peripheral smear
  • tx
A

M3 AML
t(15;17)
peroxidase positive cytoplasmic inclusions
ATRA

19
Q

night sweats, fever, fatigue, splenomegaly, increased neutrophils, metamyelocytes, and basophils

  • dx
  • blood test
  • translocation
  • tx and mechanism
A

CML
LAP (low!!! vs leukemia reaction where LAP is high)
t(9;22) - bcr-abl
imatinib (inhibits bcr-abl tyrosine kinase)

20
Q

t(9;22)

A

CML

bcr-abl

21
Q

t(8;14)

A

Burkitt lymphoma

c-myc

22
Q

t(11;14)

A

Mantle cell lymphoma

cyclin D1 activation

23
Q

t(14;18)

A

follicular lymphoma

bcl-2 activation

24
Q

t(15;17)

A

M3 AML

25
Q

child with lytic bone lesions, skin rash, recurrent otitis media, mass involving mastoid bone

  • dx
  • problem
  • cell markers
  • see what on EM
A

Langerhans cell histiocytosis

dendritic (Langerhans) cells don’t efficiently stimulate T cells via antigen presentation

S-100, CD1a

Birbeck granules (tennis rackets)

26
Q

intense itching after hot shower and maybe severe burning pain and red or blue coloration due to episodic blood clots in vessels of extremities

  • dx
  • CBC shows
  • mutation
A

polycythemia vera

Hct >55%

JAK2 mutation

27
Q

bleeding, thrombosis, large megakaryocytic

  • dx
  • mutation
A

essential thrombocytosis

JAK2

28
Q

bone marrow has few clear dots

  • dx
  • peripheral smear
  • mutation
A

myelofibrosis

teardrop RBCs

JAK2

29
Q

relative polycythemia

  • labs
  • associations
A

decrease plasma volume

dehydration
burns

30
Q

appropriate absolute polycythemia

  • labs
  • associations
A

incr RBC mass
decr O2 saturation
incr EPO levels

lung disease
congenital heart disease
high altitude

31
Q

inappropriate absolute

  • labs
  • associations
A

incr RBC mass
incr EPO!! (ectopic EPO)

renal cell carcinoma
Wilms tumor
cyst
hepatocellular carcinoma
hydronephrosis
32
Q

polycythemia vera

- labs

A

incr plasma volume
very incr RBC mass
decr EPO!

Heme Onc Path (1 decks)

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