Leukemia

Question 1

ALL ages

Answer 1

80% of acute childhood leuk, peaks b/w 3-7y/o

Question 2

ALL tx

Answer 2

Combo chemo: daunorubicin, vincristine, prednisone, asparaginase – 90% remission

Question 3

AML ages

Answer 3

median: 60 y/o

Question 4

AML prognosis

Answer 4

70-80% under 60 achieve complete remission

Question 5

AML prognostic factors

Answer 5

FAVORABLE: core binding factor (t8, 21), p13, q22
UNFAV: isolated monosomy 5 or 7, tandem duplication in FLT3 = VERY POOR prognosis

Question 6

AML pathognomonic

Answer 6

AUER ROD

Question 7

Difference b/w ALL and AML histochemistry

Answer 7

AML: peroxidase in myeloid cells and butyrate esterase in monocytic cells

Question 8

ALL and AML CD

Answer 8

ALL: NO CD3, 4, 8, but combo of 2, 5, 7
AML: CD13 and 33

Question 9

acute leukemia and infection: neutrophil count

Answer 9

<100/mcL infxn in days

Question 10

acute leukemia infxn MC pathogens

Answer 10

g-, (e. coli, klebs, pseudomonas) or fungi

Question 11

Hyperleukocytosis

Answer 11

ELEVATED BLASTS: 100k+/mcL

impaired circulation: HA, confusion, dyspnea

Question 12

Acute leukemia HALLMARK

Answer 12

pancytopenia w/ circulating blasts (absent in 10%)

Question 13

DIC

Answer 13

DEC fibrinogen, INC PT, fibrin degradation products, fibrin D-dimers