Leukemia

Question 1

M0/1/2

Answer 1

acute myeloblastic leukemia

Question 2

M3

Answer 2

Acute promyelocytic anemia

Question 3

M4

Answer 3

Acute myelomonocytic anemia

Question 4

M5

Answer 4

Acute monoblastic leukemia

Question 5

M6

Answer 5

erythroleukemia

Question 6

M7

Answer 6

Acute megakaryoblastic leukemia

Question 7

Myeloperoxidase (MPO) stain

Answer 7

stains primary granules that contain peroxidase
promyelocytes, myelocytes, metamyelocytes, bands, segs

Question 8

Sudan black B

Answer 8

stains phospholipids and other intracellular lipids found in promary and secondary granules of myeloid cells
NEGATIVE in lymphs, distinguishes ALL from AML

Question 9

Specific esterase (naphthol AS-D chloroacetate esterase)

Answer 9

primary granules of myeloid cells
Eos, monos, lymphs stain NEGATIVE

Question 10

nonspecific esterase (alpha-napthyl butyrate or alpha-napthyl acetate esterase)

Answer 10

stains monocytes

Question 11

clinical features of acute leukemia

Answer 11

dysfunctional WBCs, anemia, thrombocytopenia

Question 12

Lab features of Acute myeloid leukemia

Answer 12

Blasts
variable counts
AUER RODS
nRBC
pseudo-hyposegmentation
hypersegmentation of neutrophils

Question 13

cells that can contain auer rods

Answer 13

monoblasts
myeloblasts
promyelocytes
NOT lymphoid precursors

Question 14

auer rods are made up of

Answer 14

fused primary granules

Question 15

Acute myeloid leukemia translocation with good long term survival

Answer 15

8:21

Question 16

morphology for 8:12 translocation may contain:

Answer 16

pseudo chediak-higashi granules
pseudo pelger-huet
auer rods

Question 17

Acute promyelocytic anemia with T(15:17) findings

Answer 17

auer rods/faggot cells
procoagulant/fibrinolytic activity -> DIC
hyper/hypogranulation
R ATRA