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Leukemia > Leukemia > Flashcards

Leukemia Flashcards

1
Q

CML is Common in__________

A

Old age

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2
Q

Difference between leukemoid reaction and CML

A

Leukemoid takes leukocyte alkaline phosphatase (LAP)

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3
Q

Philadelphia chromosome( 9:22 translocation is associated with)

A

CML

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4
Q

Mgt of CML

A

Thyrosine kinase inhibitor

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5
Q

CLL is common in____________

A

Adult and old age

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6
Q

Smudge cells are seen in peripheral morphology in ____________

A

CLL
And 30% blast cells in bone marrow biopsy
Mgt IV immunoglobulin

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7
Q

Rare type of B cell neoplasm

A

Hairy cell Leukemia

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8
Q

Hairy like projection in peripheral smear and dry bone marrow biopsy shows ____________

A

Hairy cell leukemia

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9
Q

Blast referee to as

A

Defective cells which account for more than 20%

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10
Q

Hepatosplenomegally and lymphadenopathy is common in

A

ALL

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11
Q

Gum swelling due to monocyte infiltration is caused by

A

AML

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12
Q

Auer rod is seen in

A

AML(crystalized aggregates if myeloperoxidase is enzymes)

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13
Q

TDT is positive in

A

ALL

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14
Q

Trans retinoic acid

A

Helps the blast to mature in to neutrophils in case of ALL

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15
Q

AML

A

Myeloblast
Erythroblast
Leukocytes
Granulocyte

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16
Q

Thyrosine kinase inhibitor have a less effect for

A

CLL

17
Q

Blood smear of CML shows

A

Increased granules

18
Q

Hodgkin’s lymphoma risk factors

A

TB
HSV
EBV
Phenytoin

19
Q

B ssx of lymphoma

A

Fever
Night sweat
Weight loss
Others
Lymphadenopathy
Splenomegaly
Bone lesion

20
Q

Reed sternberg cells are seen in

A

Hodgkins lymphoma (large binucleat cells in biopsy)

21
Q

Remission of Hodgkin’s lymphoma is around?70-80 %

A

80

22
Q

Lymph tissues are

A

Spleen
Bone marrow
Lymph nodes

23
Q

Indulent lymphoma have

A

Long survival rate but not curable

24
Q

Richter syndrome

A

Transformation of NH lymphoma to SLL/CLL

25
Q

Indolent lymphoma

A

Follicular
SLL /CLL
Cutaneous T cell
Marginal zone

26
Q

Aggressive NH lymphoma are

A

Burkitt
Mantle cell
Follicular
Peripheral T cell
Adult T cell
Anaplastic large cell
AIDS associated
Lymphoblastic leukemia

27
Q

Risk factors for NH lymphoma

A

Hep B or c
EBV

28
Q

Cd 20 is positive for

A

B cell non Hodgkin’s lumphoma

29
Q

CD 15 and 30 is positive in

A

Hodgkin’s lymphoma

30
Q

DLBCL occurs

A

Spontaneous

31
Q

Excisional biopsy is seen in

A

Malignant lymphoma

32
Q

Motle cell lymphoma

A

Have GI ssx

33
Q

Weldenstorm myceoglobulinemia

A

Abnormal igm production
Neuropathy

34
Q

Hodgkin’s lymphoma causes hepercalcemia in what mechanism

A

Increase in alpha 1 hydroxylase activity

35
Q

Good prognosis for Hodgkin’s lymphoma

A

Young age
Lymphocytosis

36
Q

Poor prognosis for Hodgkin’s lymphoma

A

High ESR
3 or more lymph node involved
Bulky disease

37
Q

Hairy cell leukemia

A

Tartrate resistant acid phosphatase activity

Leukemia (1 decks)

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