Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Haematology > Leukaemia > Flashcards

Leukaemia Flashcards

1
Q

Where in the haematological system are leukaemias found?

A

Bone Marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the risk factors to leukaemias?

A

Radiation
Chemo
Down’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the 4 chromosmal abnormalities>

A

Translocation
Deletion
Duplication
Point Mutations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the two types of acute leukaemia?

A

Acute myeloid leukaemia

Acute Lymphoid Leukaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How can AML and ALL be differentiated?

A

Immunophenotyping and karyotyping

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

In wat age group is ALL more comon in?

A

Children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

In which age group is AML more common>

A

Adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the main features of ALL?

A

Bone marrow failure
Lymphadenopathy
Hepatosplenomegaly
Testicular Inflitration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does AML present?

A

Bone Marrow failure
Bleeding tendency
Skin and CNS inflitration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How are Acute leukaemias treated?

A

Supportive treament to symptoms

Chemo therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Who is typically affected by CLL?

A

Elderly men

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does CL usually present?

A

Indicental FBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the types of CLL and which is more common?

A

B cell - 95%

T cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What two features will be found in cytology of CLL?

A

Lymphocytosis and smear cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How is CLL treated?

A

can be ‘watched and waited’
supportive therapy
Cholorambucil (chemo)
Bone marrow transplant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What cells are over proliferative in Chronic Myeloid Leukaemia?

A

Granulocytes

17
Q

What genetic mutation is present in CML?

A

Philadephia Chromosome (translocation of chom. 9-222)

18
Q

What do patients present with in CML?

A

massive splenomegaly and hepatomegaly

19
Q

How would you investigate CML?

A

FBC for granulocytosis

genetic screen for philadelphia chromosome

20
Q

How is CML treated?

A

Imatinib

21
Q

what is imatinib? How does imatinib work?

A

it is a tyrosine kinase inhibitor

Haematology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions