Let's Go Flashcards
Bivalent and Big Direct Thrombin inhibitors
Hirudin
Bivalirudin
Hirudin is gotten from?
Recombinant of Hirudin is?
Leech saliva
Lepirudin
What type of Thrombin inhibitor is hirudin
Irreversible Thrombin inhibitor
Which DTI has short half life with clearance of 20% and remainder metabolic?
Bivalirudin
Is bivalirudin hirudin analogue??
Yes
Is bivalirudin hirudin analogue??
Yes
Which Direct Thrombin inhibitor is used in combination with Aspirin and clopidogrel in patients undergoing percutaneous coronary artery surgery?
Bivalirudin
Which Direct Thrombin inhibitor inhibit platelet activation
Bivalirudin
Which other DTI has short half life aside bivalirudin
Which direct Thrombin inhibitor is a substrate for P- glycoprotein efflux pump ?
Dabigatran
Half life of dabigatran?
12-17hrs
In what condition do you see warfarin resistance?
Advance cancers; Trousseau syndrome
Which drug is superior to warfarin in preventing recurrent venous thromboembolism seen in cancer patients?
LMW heparin
Mention the pharmacokinetic drugs that potentiate warfarin action??
Inducers
Amoidarone
Cimetidine
Ceptrin
Metronidazole
Azoles
Disulfiram
Sulfinpyrazone
Drugs that decrease prothrombin time, hence inhibiting warfarin action?
Barbiturates
Rifampin
Cholestyyramine
Pharmacodynamic drugs that potentiate warfarin hence increasing PT time
HMW and LMW heparin
Cephalosporin…inhibit reduction of Vitamin K
Aspirin: inhibits platelet fxn
List the pharmacodynamic body factors that potentiate aspirin
Hepatic disease
Hyperthyroidism
Fever
Pharmacodynamic drugs and body factors that reduce warfarin effect… reducing PT
Drugs:
Diuretics
Vitamin K
Body factors; Hereditary resistance.
Hypothyroidism
Oral direct factor Xa inhibitors has rapid onset of action and shorter half life than warfarin true of false??
True
Oral direct factor Xa inhibitors has rapid onset of action and shorter half life than aspirin true of false??
True
