Lessons 2 Flashcards
Candida albicans
Topical azoles (vaginitis); nystatin, fluconazole, caspofungin (oral/esophageal); fluconazole, caspofungin, amphotericin B (systemic)
Cryptococcus neoformans
Induction with amphotericin B and flucytosine, maintenance with fluconazole (in AIDS patients
Sporothrix schenckii
Itraconazole, oral potassium iodide
Pneumocystis jirovecii
TMP-SMX (prophylaxis and treatment in immunosuppressed patients, CD4 < 200/mm3)
Toxoplasma gondii
Sulfadiazine + pyrimethamine
Malaria
Chloroquine, mefloquine, atovaquone/proguanil (for blood schizont), primaquine (for liver hypnozoite)
Trichomonas vaginalis
Metronidazole (patient and partner)
Streptococcus pyogenes
Penicillin prophylaxis
Streptococcus pneumoniae
Penicillin/cephalosporin (systemic infection, pneumonia), vancomycin (meningitis)
Staphylococcus aureus
MSSA: nafcillin, oxacillin, dicloxacillin (antistaphylococcal penicillins); MRSA: vancomycin, daptomycin, linezolid, ceftaroline
Enterococci
Vancomycin, aminopenicillins/cephalosporins
Rickettsia rickettsii
Doxycycline, chloramphenicol
Clostridium difficile
Oral metronidazole; if refractory, oral vancomycin
Mycobacterium tuberculosis
RIPE (rifampin, isoniazid, pyrazinamide, ethambutol)
UTI prophylaxis
TMP-SMX
Influenza
Oseltamivir, zanamivir
CMV
Ganciclovir, foscarnet, cidofovir
Patent ductus arteriosus
Close with indomethacin; keep open with PGE analogs
Stable angina
Sublingual nitroglycerin
Buerger disease
Smoking cessation
Kawasaki disease
IVIG, aspirin
Temporal arteritis
High-dose steroids
Granulomatosis with polyangiitis (Wegener)
Cyclophosphamide, corticosteroids
Hypercholesterolemia
Statin (first-line)
Hypertriglyceridemia
Fibrate
Arrhythmia in damaged cardiac tissue
Class IB antiarrhythmic (lidocaine, mexiletine)
Prolactinoma
Cabergoline/bromocriptine (dopamine agonists)
Diabetes insipidus
Desmopressin (central); hydrochlorothiazide, indomethacin, amiloride (nephrogenic)
SIADH
Fluid restriction, IV hypertonic saline, conivaptan/ 338 tolvaptan, demeclocycline
Diabetic ketoacidosis
Fluids, insulin, K+
Diabetes mellitus type 1
Dietary intervention (low carbohydrate) + insulin 347 replacement
Diabetes mellitus type 2
Dietary intervention, oral hypoglycemics, and insulin (if refractory)
Pheochromocytoma
α-antagonists (eg, phenoxybenzamine)
Carcinoid syndrome
Octreotide
Crohn disease
Corticosteroids, infliximab, azathioprine
Ulcerative colitis
5-ASA preparations (eg, mesalamine), 6-mercaptopurine, infliximab, colectomy
Sickle cell disease
Hydroxyurea (fetal hemoglobin increased)
Chronic myelogenous leukemia
Imatinib
Acute promyelocytic leukemia (M3)
All-trans retinoic acid, arsenic trioxide
Drug of choice for anticoagulation in pregnancy or renal failure
Low-molecular-weight heparin
Heparin reversal
Protamine sulfate
Immediate anticoagulation
Heparin
Long-term anticoagulation
Warfarin, dabigatran, rivaroxaban and apixaban
Warfarin reversal
Fresh frozen plasma (acute), vitamin K (non-acute)
Cyclophosphamide-induced hemorrhagic cystitis
Mesna
HER2/neu ⊕ breast cancer
Trastuzumab
Osteoporosis
Calcium/vitamin D supplementation (prophylaxis); 462 bisphosphonates, PTH analogs, SERMs, calcitonin,
denosumab (treatment)
Osteomalacia/rickets
Vitamin D supplementation
Chronic gout
Xanthine oxidase inhibitors (eg, allopurinol, febuxostat); pegloticase; probenecid
Acute gout attack
NSAIDs, colchicine, glucocorticoids
Neural tube defect prevention
Prenatal folic acid
Migraine
Abortive therapies (eg, sumatriptan, NSAIDs); prophylaxis eg, propranolol, topiramate, CCBs, amitriptyline)
Multiple sclerosis
Disease-modifying therapies (eg, β-interferon, natalizumab); for acute flares, use IV steroids
Tonic-clonic seizures
Levetiracetam, phenytoin, valproate, carbamazepine
Absence seizures
Ethosuximide
Trigeminal neuralgia (tic douloureux)
Carbamazepine
Malignant hyperthermia
Dantrolene
Anorexia
Nutrition, psychotherapy, SSRIs
Bulimia nervosa
SSRIs
Alcoholism
Disulfiram, acamprosate, naltrexone, supportive care
ADHD
Methylphenidate, amphetamines, CBT, atomoxetine, guanfacine, clonidine
Alcohol withdrawal
Long-acting benzodiazepines
Bipolar disorder
Mood stabilizers (eg, lithium, valproic acid, carbamazepine), atypical antipsychotics
Depression
SSRIs (first-line)
Generalized anxiety disorder
SSRIs, SNRIs (first line); buspirone (second line)
Schizophrenia (positive symptoms)
Typical and atypical antipsychotics
Schizophrenia (negative symptoms)
Atypical antipsychotics
Hyperaldosteronism
Spironolactone
Benign prostatic hyperplasia
α1-antagonists, 5α-reductase inhibitors, PDE-5 inhibitors
Infertility
Leuprolide, GnRH (pulsatile), clomiphene
Breast cancer in postmenopausal woman
Aromatase inhibitor (anastrozole)
ER ⊕ breast cancer
ER ⊕ breast cancer
Tamoxifen
Prostate adenocarcinoma/uterine fibroids
Leuprolide, GnRH (continuous)
Medical abortion
Mifepristone
Prostate adenocarcinoma
Flutamide
Erectile dysfunction
Sildenafil, tadalafil, vardenafil
Pulmonary arterial hypertension (idiopathic)
Sildenafil, bosentan, epoprostenol
Mitochondrial inheritance
Disease occurs in both males and females, inherited through females only
Intellectual disability
Down syndrome, fragile X syndrome
Vitamin deficiency (USA)
Folate (pregnant women are at high risk; body stores only 3- to 4-month supply; prevents neural tube defects)
Lysosomal storage disease
Gaucher disease
Bacterial meningitis (adults and elderly)
S pneumoniae
Bacterial meningitis (newborns and kids)
Group B streptococcus/E coli/Listeria monocytogenes (newborns), S pneumoniae/N meningitidis (kids/teen
HLA-DR3
Diabetes mellitus type 1, SLE, Graves disease, Hashimoto thyroiditis (also associated with HLA-DR5), Addison disease
HLA-DR4
Diabetes mellitus type 1, rheumatoid arthritis, Addison disease
Bacteria associated with gastritis, peptic ulcer disease, and gastric malignancies (eg, adenocarcinoma, MALToma)
H pylori
Opportunistic infection in AIDS
Pneumocystis jirovecii pneumonia
Helminth infection (US)
Enterobius vermicularis
Viral encephalitis affecting temporal lobe
HSV-1
Infection 2° to blood transfusion
Hepatitis C
Food poisoning (exotoxin mediated)
S aureus, B cereus
Osteomyelitis
S aureus (most common overall)
Osteomyelitis in sickle cell disease
Salmonella
Osteomyelitis with IV drug use
Pseudomonas, Candida, S aureus
UTI
E coli, Staphylococcus saprophyticus (young women)
Sexually transmitted disease
C trachomatis (usually coinfected with N gonorrhoeae)
Nosocomial pneumonia
S aureus, Pseudomonas, other enteric gram ⊝ rods
Pelvic inflammatory disease
C trachomatis, N gonorrhoeae
Infections in chronic granulomatous disease
S aureus, E coli, Aspergillus (catalase ⊕)
Metastases to bone
Prostate, breast > kidney, thyroid, lung
Metastases to brain
Lung > breast > melanoma, colon, kidney