Lesson 8 | Cerebrospinal fluid Flashcards
One of the most commonly performed tests for CSF
Cerebrospinal Fluid Proteins
Normal value for CSF Proteins
15 - 45mg/dL
Major protein for CSF Protein
Albumin
2nd most prevalent CSF Protein
Prealbumin
Alpha-globulin
Haptoglobin
Ceruloplasmin
Major beto-globulin
Transferrin
Binds to iron in the blood
Transferrin
Gamma globulins
Primarily IgG
Small amounts of IgA
Carbohydrate-deficient transferrin fraction seen only in CSF
tau
Qualitative test for CSF Proteins
Nonne-Apelt
Rose-jonse
Pandy’s
Nogochi
Colloidal Gold test
Quantitative test for CSF Proteins
Turbidimetric
Automation
Dye-binding technique
Biuret method
Electrophoresis
For CSF Glucose, blood glucose should be drawn _____
2 hours before spinal tap
In CSF Glucose it compares ____
CSF and Blood glucose
Normal value of CSF Glucose
60-70% of plasma glucose
Decreased glucose values
Bacterial meningitis
Tubercular meningitis
Normal glucose values
Viral meningitis
Increased glucose values
Diabetes
Encephalitis
Intracranial pressure
Clinical uses of Lactate
Meningitis
Tissue destruction
Severe head injuries
False increase
Product of bacterial metabolism
Lactate
Normal value of CSF Glutamine
10-24mg/dL
Range for bacterial meningitis
> 35mg/dL
Range for viral meningitis
<25mg/dL
CSF glutamine is produced by CNS by brain cells from
Ammonia and Alpha-ketoglutarate
Increased in glutamine and ammonia
=brain damage
Normal values of CSF glutamine
8-18 mg/dL
Indirect test for the presence of excess ammonia of the CSF
CSF glutamine
Increased lactate values in
Liver disorders
Reyse’s syndrome
Coma of unknown origin
