Lesson 7: Mycobacterium species Flashcards
General description of Mycobacterium spp.
✓ Acid-fast rods (Ziehl Nelseen-positive)
✓ Aerobic, non-motile, non-spore-forming
✓ Pathogenic species grow slowly, colonies visible after several weeks
Cell walls of Mycobacterium spp. are rich in what?
complex lipids and waxes containing mycolic acids
Mycobacterium spp. type of media required for growth of pathogenic species
Complex egg-enriched media
Genus of Mycobacterium spp.
✓ obligate pathogens
✓ opportunistic pathogens
✓ saprophytes
It grow slowly, colonies visible after several weeks
Pathogenic species
Some mycobacteria produce these pigments
carotenoid pigments
Mycobacterium spp. are resistant to what?
✓ chemical disinfectants
✓ environmental influences
Mycobacterium spp. are susceptible to what?
heat treatment (pasteurization)
Mycobacterium spp. multiply intracellularly and cause these infections
chronic, granulomatous infections
Major diseases caused by Mycobacterium spp.
✓ tuberculosis
✓ Johne’s disease
✓ feline leprosy
Staining method used in the Mycobacterium spp.
Ziehl-Nelseen Method
the mycobacteria stain color is what?
red (acid-fast)
Tuberculosis (worldwide) is caused by what bacteria?
M. tuberculosis
Tuberculosis in (East. Africa) is caused by what bacteria?
M. africanum
Tuberculosis in (West. Africa) is caused by what bacteria?
M. canettii
Buruli cancer is caused by what bacteria?
*M. ulcerans
*
Leprosy is caused by what bacteria?
M. leprae
Rat leprosy and feline leprosy are caused by what bacteria?
M. lepraemurium
Paratuberculosis (Johne’s Disease)
is caused by what bacteria?
M. avium subsp. paratuberculosis
Associated with skin tb is caused by what bacteria?
Unspecified acid-fast bacteria
bovine farcy is caused by what bacteria?
✓ M. senegalensi
✓ M. farcinogenes
Bacteria that causes tuberculosis
- M. tuberculosis
M. africanum
M. canettii
M. microti
M. caprae
M. pinnipedii
M. avium complex
M. marinum*
Main host of M. tuberculosis
✓ humans
✓ captive
primates
Main host of M. tuberculosis
Cattle
Main host of M. africanum
Humans
Main host of M. canettii
Humans
Main host of M. microti
Voles
Main host of M. caprae
Goats
Main host of M. pinnipedii
✓ seals
✓ sea lions
Main host of M. avium complex
Most avian species
except psittacine
Main host of M. marinum
Fish
Main host of M. ulcerans
Human
Main host of M. leprae
Human
Main host of M. lepraemurium
✓ rats
✓ mice