Lesson 7

Question 1

Antigen processing

Answer 1

The process by witch an antigen on a pathogen is ligated to the HLA

Question 2

Antigen presentation

Answer 2

Antigen peptides expressed on cell membrane and presented to T lymphocytes for adaptive immune activation

Question 3

Origin of antigen peptides

Answer 3

Endogenous proteasome activation Th1 or exogenous phagolysosome activating Th2

Question 4

HLA differences

Answer 4

hla1 is involved in cellular immunity while hla 2 is involved in activation humoral immunity

Question 5

How is antigen degradation in HLA-1 antigen processing? In HLA 2?

Answer 5

1. Through degradation in proteosome and then transport into e.r thanks to TAP, and then ligated to HLA with help of cal chaperones and tapsin(necessary for assembly) 2. Hapenns in phagolysosome qith lysososomal and endosomal enzymes and the help of HLA-DM

Question 6

What is necessary for transport of peptides from proteasome to HLA complex

Answer 6

TAP transporter

Question 7

Where are antigens ligated to the HLA complex

Answer 7

E.R or Phagolysosome

Question 8

Where are MHC class 1 molecules assembled

Answer 8

In the endoplasmic reticulum

Question 9

What cluster of differentiation do HLA1 complexes interact with, On what t cell

Answer 9

CD8 on cytotoxic t cells triggering release of cytotoxic cytokines

Question 10

How is appropriate folding of alpha chains carried out

Answer 10

With the help of tapsin and calnexin and calreticuline

Question 11

What’s a necessity for Proper class 1 HLA light and heavy chain assembly

Answer 11

Tapsin

Question 12

What does CLIP do with HLA1 or 2

Answer 12

Blocks peptide interaction with HLA 2 in vesicles transporting to Phagolysosome (prior to that its an invariable chain, cleaved with vesicle formation)

Question 13

Whos responsible for ligating HLA2 with Antigen

Answer 13

HLA DM