Lesson 5 - PTSD Flashcards

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1
Q

Kent County Lunatic Hospital

A

Also called Oakwood Hospital. Located in Maidstone, England. This 19th century asylum housed ~2000 psychiatric patients. In the mid-nineteenth century, the superintendent of the asylum was Dr James Huxley (1821-1907), the elder brother of Thomas Henry Huxley, the evolutionary biologist and friend of Charles Darwin.

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2
Q

Charles Dickens developed PTSD after which railway crash and when?

A

Great Staplehurst Railway Crash, 1865.

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3
Q

Who was Gilgamesh and why did he likely develop PTSD?

A

Ancient Mesopotamian demigod, developed PTSD over the death of his beloved Enkidu. One of the older recorded stories in history.

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4
Q

What happened after the battle of Marathon, when was it, and what is the significance?

A

An Athenian soldier was blinded by the trauma he witnessed during the war, an early example of PTSD symptoms. 490 BCE.

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5
Q

What did Emil Kraepalin contribute to the field of psychology?

A

Developed psychiatric nosology - classifying mental disorders based on clinical characteristics and course of illness. Described anxiety symptoms after traumas as “fright neurosis.” Laid the groundwork for understanding trauma disorders and PTSD.

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6
Q

What was “traumatic hysteria” and who (two) proposed it as a diagnosis?

A

Jean Charcot & Pierre Janet, expanded on Kraepalin’s findings. Indentified the relationships btwn traumas and psychological symptoms.

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7
Q

What was “male hysteria” and who proposed it as a diagnosis?

A

**Jean Charcot, who rejected the idea that so-called “hysteria” was unique to women. **Male hysteria was more commonly associated with traumatic injury from war or accidents, or with symptoms of Tourette’s syndrome, and was considered a distinct disease from female hysteria. So gendered stereotypes were definitely alive and well with Charcot, but the idea that women were not the only mentally ill ones was revolutionary to white people.

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8
Q

19th Century treatments for hysteria

A

Hysterectomy, sex or rape, magnetism, bed rest, and many other “treatments.”

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9
Q

Symptoms of “traumatic hysteria”

A

Seizures, vomiting, blindness, paralysis, pain, sensory impairment, dissociation of traumatic memories from everyday consciousness.

Memories of traumas return as intense emotional
reactions, aggressive behavior, physical pain, and
bodily states.

Charcot linked physical symptoms to intense fright mediated by unconscious mental processes.

Traumatic hysteria originated from the patient’s ideas about the traumatic event. The emotion experienced at the time of the accident determined the hysterical symptom.

Traumatic hysteria seen as a manifestation of hysteria due to psychological impact of physical trauma, regardless of gender.

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10
Q

What is trauma according to classical conditioning?

A

Trauma triggers intense emotional responses linked to specific cues or stimuli.

Classical conditioning explains the association
between trauma and behavior. Trauma-related stimuli can act as triggers for conditioned responses. Conditioned responses involve intense emotional or physiological reactions.

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11
Q

What is trauma-response generalization?

A

Generalized conditioned responses to stimuli similar to the original trauma, e.g. reacting to cars backfiring like the sound of a gunshot. In other words, being triggered in more situations than before.

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12
Q

What is shell shock and what is its relationship to traumatic hysteria?

A

Traumatic hysteria became known as shell shock during WWI due to its association with wartime bombings. Shell shock was said to have emotional origins but was also attributed to underlying personality defects.

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13
Q

What were the treatments for shell shock?

A

Initial treatments were just disciplinary: “Get your act together!” Later, hypnosis and abreaction were used to treat symptoms and process traumatic memories.

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14
Q

What were the Richmond, Netley, and Seale Hayne Military Hospitals and what is their importance?

A

These are British war hospitals. They treated psychiatric patients with shell shock during and post-WWI.

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15
Q

How successful were the treatments for shell shock and why?

A

The war hospitals had very high recovery rates for shell shock, though there was no universal or rapid cure for the condition.

Patients who didn’t respond to the hypnosis and abreaction treatments were sent to different facilities and eventually institutionalized in asylums.

The high success rate was due to: 1) institutional structure and support; 2) break from war stress and trauma; 3) use of talk-therapy to process emotions and heal.

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16
Q

Name all the prior versions of PTSD in the DSM, including the current one

A

DSM-I (1952): Gross stress reaction
DSM-II (1968): Transient situational disturbance
DSM-III (1980): PTSD - huge emphasis on the “severity” (as determined by doctor) of the trauma experience, rather than the symptoms of the patient. Only big-T Traumas counted as PTSD.
DSM-IV (1994): PTSD - Diagnostic criteria now included symptoms from each of three clusters: intrusive recollections, avoidant/numbing symptoms, and hyper-arousal symptoms. Symptoms must be of significant duration and must cause significant distress or functional impairment.
DSM-5 (2013): PTSD - Definition expanded to include negative cognitions and mood states as well as disruptive behavioral symptoms. No longer categorized as an Anxiety Disorder, but as a Trauma- and Stressor-Related Disorder.

17
Q

What is the ICD-11?

A

It is the international psychiatric diagnostic manual published by the World Health Organiazation. It classifies disorders and gives us common language to speak about these conditions.

18
Q

What are the diagnostic criteria for PTSD?

A
  1. A direct trauma, or multiple indirect traumas.
  2. Intrusive recollections (flashbacks), avoidant and/or numbing behaviours, and hyper-arousal.
  3. Negative cognitions and mood states.
  4. Disruptive behaviours.
  5. Symptoms must be of significant duration and cause significant distress or functional impairment.
19
Q

What is Complex PTSD (C-PTSD)?

A

Cause: It develops after exposure to prolonged or repetitive extremely threatening events. Symptoms: Severe and persistent problems in affect regulation, negative self-beliefs, and difficulties in relationships.

Children and adolescents are particularly vulnerable to developing Complex PTSD when exposed to severe and prolonged trauma. It has a high comorbidity rate with other disorders.

20
Q

What is the prevalence of PTSD?

A

6.1 - 9.2% of the population in the U.S. and Canada. Of course, background matters! People in countries with active conflicts are several times more likely to develop PTSD in their lifetime. Indigenous people in the U.S. have a 14.2 - 16.1% prevalence of PTSD, and PTSD prevalence sits at around 37% in post-conflict Algeria.

21
Q

What are the risk factors for PTSD?

A

Prior trauma, childhood adversity, personal and familial psychiatric history, poor social support, physical injury, and the initial severity of the reaction to the traumatic event.

22
Q

What is pathophysiology?

A

The abnormal physiological processes contributing to a disorder.

23
Q

What is the pathophysiology of PTSD?

A

We don’t know yet, but neuroimaging suggests conditioned responses and a failure to eliminate fear. It also shows disruptions in brain regions concerning fear learning and salience processing, reduced hippocampal volume.

24
Q

What are the modern treatments for PTSD?

A

Trauma-focused psychotherapy (aka EMDR) is the primary treatment method nowadays, and is preferred over mediction for adults with PTSD. SSRIs are typically used only when the patient has other disorders that would benefit from the medication.

25
Q

What is epigenetics?

A

Epigenetics is the process through which the environment a parent lives in influences the genes they pass on to their children. In formal terms, it is the influence of the environment of an individual on the genome. “Genes have memory.”

26
Q

How does epigenetics work?

A

Genes are turned on or off, but are not altered themselves. This is done by methylation or histone modification.

27
Q

What are the two main types of methylation and how do they work?

A

Methyl groups (CH3 molecules) attached to DNA molecules influence gene expression.
Hypermethylation: more attached methyl groups = gene suppression.
Hypomethylation: fewer attached methyl groups = gene activation.

28
Q

What was the impact of the Dutch Hunger Winter during WWII? State the limitations of the report. How were these resolved?

A

Long-term exposure to famine in pregnant folks led to a 2x** increase in schizophrenia risk for those exposed during their first trimester.**

Limitations included the overwhelmingly white race of participants and possible alternative explanations, like tulip bulb toxicity.

The study’s findings were replicated by those after the Chinese famine. This provided cross-racial evidence in the absence of likely tulip bulb toxicity.

29
Q

What effects does PTSD have on pregnancy?

A

Low basal cortisol levels in parent and child.
-> Cortisol was lowest in the child when trauma was experienced in the parent’s third trimester.
-> Low basal cortisol = impaired stress response = difficult to respond to and recover from stress.

Twice as likely to develop schizophrenia if trauma was experienced in first trimester.

30
Q

What is the methylation pattern of Holocaust survivors like?

A

Low levels of NR3C1 gene activation. The NR3C1 gene encodes the glucocorticoid receptor, which helps regulate the body’s reaction to stress and inflammation. Survivors are more likely to have internalizing disorders like anxiety, depression, or PTSD. (Who’d have thunk it.)

31
Q

What was the Cherry Blossom study and what did it find?

A

Researchers blew acetophenone (cherry blossom smell) through the cages of adult male mice. Mice were zapped with an electric current at the same time.

Over several repetitions, the mice associated the smell of cherry blossom with pain.

When their pups smelled the scent of cherry blossom, they became jumpier and more nervous than pups whose fathers hadn’t been conditioned to fear it.