Lesson 4: Other Serologic Test Flashcards
What cells that acts as memory cells so that by the second time that the same antigen enters the body, the IS will trigger its immune response by algorithmically rising the titer of the antibody to completely eliminate the ag to avoid infection
-T cells
What are the two main acetylcholic receptor found in the body?
- nicotinic type
- muscarinic type
T/F. AChR is also known as ionotropic.
true
What term is used in muscarinic type wherein it does need any ion/s since it metabolizes the ions in that particular receptor site
metabotropic
An antibody that is used to diagnose acquired myasthenia gravis wherein if increased or more than 0.03 nmol/L is already suggestive of MG.
acetylcholine receptor antibody
An autoimmune that causes muscle weakness d/t a circulating ab that blocks acetylcholine receptor
myasthenia gravis
What autoimmune disease char. by excessive fatigability and weakness, diplopia, ptosis of the eye, facial weakness, dysphonia and difficulty in swallowing and chewing
myasthenia gravis
ACh that are not bound to the receptor site will be hydrolyzed or destroyed by
acetyl cholinesterase
The AP should be enough in the SR in order for the calcium ion channels to open to ____
myofibrils = muscle contraction
What is the hallamrk of Myasthenia Gravis
ptosis of the eye
It is noninvasive and most common test in MG wherein its principle: Acetylcholinesterase is inhibited in lower temp and also, temp detaches the ab from the receptor
Ice test. if Pos in ice test proceed to more diagnostic and definitive test
Are cholinesterase inhibitors that are definitive and diagnostic test. Side effect of these drugs are cardiac arrest
prostigmine
edrophonium
A rare autoimmune disorder that affects the calcium dependent channels in the SR
Lambert-Easton Myasthenic Syndrome
A defensive substance in the body that is a serine protease inhibitor
Alpha 1 protease inhibitor
one of the most potent protease enzyme
trypsin
Deficient or absent serum levels of AAT is used to diagnose __
emphysema
A protein that helps or contributed the elasticity fo the lungs
elastin
Emphysema is subdivided into two parts. What part is related to AAT deficiency, affectign the alveoli d/t loss of elasticity and is more common in young adults
Panacinar
What type of emphysema that is d/t destruction of terminal bronchioli muchosis secondary to chronic bronchitis and found mostly in elderly peeps with long hiustory of smoking
centroacinar
What is the chemical name for SACE
peptidyldipeptide hydrolase
What is the other name for sarcoidosis?
Besnier-Boeck disease
A multisystem disorder char. by formation of granulomas in the epithelial cells of the affected tissue
Besnier-Boeck disease/ Sarcoidosis
Which of the ff. are used in diagnosing Besnier-Boeck Disease?
a. IV endrophonium test
b. Curare provocation test
c. Intracutaneous Kvein Test
d. Inramuscular Prostigmine test
c. Intracutaneous Kvein test
A hormone system that regulates blood pressure and water balance
Renin-angiotensin-aldosterone-system
Stimulus of the hormone that regulates bp and water balance
decrease in bp and water retention
What is the first action of Angiotensin 2?
Act on adrenal cortex
Enumerate the actions of Angiotensin 2 in order
Acts on adrenal cortex to release aldosterone
Active sympathetic activity - increase salt appetite
vasoconstrictor
ADH - water reabsorption; also known as vasopressin
Also known as Scl-70 antibody
Antiscleroderma antibody
A antinuclear antibody that is diagnostic for scleroderma especially for Progressive systematic scleroderma
Antiscleroderma antibody
Angiotensin II will immediately inhibit all the vasodilator in kinin system. What are those vasodilator?
bradykinin and kallidin
ADH also known as
vasopressin
What is used in Scleroderma in order to diagnose the px?
FANA
What pattern of FANAthat results to a total nuclear fluorescence
homogenous/diffuse pattern
What pattern in the FANA wherein the fluorescence occurs at the edges of the nucleus
peripheral/outline
What FANA pattern wherein fluorescence is seen in numerous numbers / scattered inside the nucleus
Speckled pattern
Fluorescence at the center of the nucleus or near eccentric; seen as compact or solide pattrn
nucleolar pattern
An antinnuclear antibody that is used to support diagnosis of CREST syndrome
Anticentromere antibody
It is a limited form of scleroderma
CREST
An antinuclear antibody that is used to support in diagnosis of the limited form of scleroderma
Anticentromere antibody
the formation of tiny deposits of calcium in the skin
calcinosis
a vasopastic disorder causing discoloration of the fingers, toes and other extremities
Raynaud’s syndrome
Associated with the poor functioning muscle of the lower 2/3’s of the esophagus. It yield a wide opening of the esophageal tissue
esophageal dysmotility
the localized thickening and tightness of the skin of the fingers and toes
sclerodactyly
tiny red areas of the face, mouth, hands, mucous membranes ans even in the extremities; cause dilated capillaries that lead to extravasation of the RBC
telangiectasias
Which of the ff. that causes the telangiectasias?
a. calcium deposits to the fingers, knees and elbows
b. dilated cappilaries in the surroundign connective tissues attacked by the Ab
c. thickening and tightness of the skin
d. vasospasm in the arterioles
b. dilated cappilaries in the surroundign connective tissues attacked by the Ab
An antibody used primarily to aid in the diagnosis of the autoimmune chronic active hepatitis (CAH)
Anti Smooth muscle antibody
t/f. ASMA is also used to diagnose SLE
true
Which of the ff is true about CAH?
a. also referred as lupoid hepatitis
b. char. histologically by periportal necrosis and plasma infiltration in of the portacl tracts
c. Manifestation should exist over 5 months before it is considered as CAH
d. all of the above
e. 1 is true; 2 are false. Identify which
f. 2 are true; 1 is false. identify asa
f. only letter c is false kay 6 mos
Type fo CAH where it is char. by the presence of ASMA, also has ANA and it the most prevalent
type 1 cah
What type of CAH that is seen with othwr autoimmune diseases such as hyperthyroidism and Coomb’s positive hemolytic anemia
type 1
What type of CAH that is char. by the presence of antiliver-kidney microsomal antibodies
type 2
What type of CAH that is dominant to pediatric and associated to autoimmune disorder such as insulin-dependent diabetes and autoimmune thyroid disease
type 2 cah
type of CAh that is char. by the presence of anti-soluble liver antigen (anti-SLA)
type 3 cah
Antinuclear antibodies that are extracted from the nucleus of thr human B lymphocytes
anti ssa
anti ssb
anti ssc
What pattern presents the La and Ro under uv microscope
speckled apttern
It is used in the diagnosis of Sjogren’s syndrome. iodentify if it is for primary or secondary
Anti-La (more specific) and ANti-Ro for primary
Anti-SSC secondary
An autoimmune disorder that affects the exocrine glands
Sjogren’s syndrome
T/F. Secondary Sjogren’s is associated with autoimmune disease such as RA
true
Enumerate the test used for Keratoconjuctivitis sicca
schirmer test
rose bengal test
A test for KCS that is done without anesthesia. it measures the production of tears. If positive, wetness of the eye measures <5 mm for 5 minutes
schirmer test
A test for KCS that uses a supravital stain that stains the cell or tissue of conjunnctivitis and cornea of the eye
rose bengal test
What stain is used to stain the surface of the cornea and conjunctiva
rose bengal stain
Rose bengal stain is not a flourescein stain but a derivative. It is derived from?
tetrachloro tetraiodo fluorescein dye
What scoring system is used in Rose bengal test?
Van Bijsterveld’s scoring system
A test that collects saliva and determine the volume of the salive produced in a 5 minute period
Salivary Function Test
A lip tissue will reveal proliferation of lymphocytes/antibodies
lip biopsy
it is used to assis in the diagnosis of SLE and MCTD. The antigen is extracted from the thymus
antiextractable nuclear antigen
ANtibody that is sensitive to SLE
anti-smith
antibody that is sensitive to MCTD
Anti-ribonucleoprotein
Also referred as Fern TEst
cervical mucus
It is used to indicate the timing ovulation and evaluation of infertility
cervical mucus
It detects the ability for the cervical mucus to provide an optimal environment for the sperm cells to enter the fallopian tube
SIMS-HUHNER TEST
It measures the ability of the sperm to penetrate mucus and maintain motility
sims-huhner
T/F. LH and Estrogen is decreased in menstruation cycle esp. in the midcycle
false. decreased
It is an abnormal dropping of the upper eyelid when the eyes of yhe px is looki g straight ahead
Blepharoptosis
