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Seminar 2 > Lesson 4: Other Serologic Test > Flashcards

Lesson 4: Other Serologic Test Flashcards

1
Q

What cells that acts as memory cells so that by the second time that the same antigen enters the body, the IS will trigger its immune response by algorithmically rising the titer of the antibody to completely eliminate the ag to avoid infection

A

-T cells

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2
Q

What are the two main acetylcholic receptor found in the body?

A
  1. nicotinic type
  2. muscarinic type
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3
Q

T/F. AChR is also known as ionotropic.

A

true

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4
Q

What term is used in muscarinic type wherein it does need any ion/s since it metabolizes the ions in that particular receptor site

A

metabotropic

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5
Q

An antibody that is used to diagnose acquired myasthenia gravis wherein if increased or more than 0.03 nmol/L is already suggestive of MG.

A

acetylcholine receptor antibody

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6
Q

An autoimmune that causes muscle weakness d/t a circulating ab that blocks acetylcholine receptor

A

myasthenia gravis

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7
Q

What autoimmune disease char. by excessive fatigability and weakness, diplopia, ptosis of the eye, facial weakness, dysphonia and difficulty in swallowing and chewing

A

myasthenia gravis

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8
Q

ACh that are not bound to the receptor site will be hydrolyzed or destroyed by

A

acetyl cholinesterase

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9
Q

The AP should be enough in the SR in order for the calcium ion channels to open to ____

A

myofibrils = muscle contraction

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10
Q

What is the hallamrk of Myasthenia Gravis

A

ptosis of the eye

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11
Q

It is noninvasive and most common test in MG wherein its principle: Acetylcholinesterase is inhibited in lower temp and also, temp detaches the ab from the receptor

A

Ice test. if Pos in ice test proceed to more diagnostic and definitive test

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12
Q

Are cholinesterase inhibitors that are definitive and diagnostic test. Side effect of these drugs are cardiac arrest

A

prostigmine
edrophonium

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13
Q

A rare autoimmune disorder that affects the calcium dependent channels in the SR

A

Lambert-Easton Myasthenic Syndrome

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14
Q

A defensive substance in the body that is a serine protease inhibitor

A

Alpha 1 protease inhibitor

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15
Q

one of the most potent protease enzyme

A

trypsin

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16
Q

Deficient or absent serum levels of AAT is used to diagnose __

A

emphysema

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17
Q

A protein that helps or contributed the elasticity fo the lungs

A

elastin

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18
Q

Emphysema is subdivided into two parts. What part is related to AAT deficiency, affectign the alveoli d/t loss of elasticity and is more common in young adults

A

Panacinar

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19
Q

What type of emphysema that is d/t destruction of terminal bronchioli muchosis secondary to chronic bronchitis and found mostly in elderly peeps with long hiustory of smoking

A

centroacinar

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20
Q

What is the chemical name for SACE

A

peptidyldipeptide hydrolase

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21
Q

What is the other name for sarcoidosis?

A

Besnier-Boeck disease

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22
Q

A multisystem disorder char. by formation of granulomas in the epithelial cells of the affected tissue

A

Besnier-Boeck disease/ Sarcoidosis

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23
Q

Which of the ff. are used in diagnosing Besnier-Boeck Disease?

a. IV endrophonium test
b. Curare provocation test
c. Intracutaneous Kvein Test
d. Inramuscular Prostigmine test

A

c. Intracutaneous Kvein test

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24
Q

A hormone system that regulates blood pressure and water balance

A

Renin-angiotensin-aldosterone-system

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25
Q

Stimulus of the hormone that regulates bp and water balance

A

decrease in bp and water retention

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26
Q

What is the first action of Angiotensin 2?

A

Act on adrenal cortex

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27
Q

Enumerate the actions of Angiotensin 2 in order

A

Acts on adrenal cortex to release aldosterone
Active sympathetic activity - increase salt appetite
vasoconstrictor
ADH - water reabsorption; also known as vasopressin

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28
Q

Also known as Scl-70 antibody

A

Antiscleroderma antibody

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29
Q

A antinuclear antibody that is diagnostic for scleroderma especially for Progressive systematic scleroderma

A

Antiscleroderma antibody

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30
Q

Angiotensin II will immediately inhibit all the vasodilator in kinin system. What are those vasodilator?

A

bradykinin and kallidin

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31
Q

ADH also known as

A

vasopressin

32
Q

What is used in Scleroderma in order to diagnose the px?

A

FANA

33
Q

What pattern of FANAthat results to a total nuclear fluorescence

A

homogenous/diffuse pattern

34
Q

What pattern in the FANA wherein the fluorescence occurs at the edges of the nucleus

A

peripheral/outline

35
Q

What FANA pattern wherein fluorescence is seen in numerous numbers / scattered inside the nucleus

A

Speckled pattern

36
Q

Fluorescence at the center of the nucleus or near eccentric; seen as compact or solide pattrn

A

nucleolar pattern

37
Q

An antinnuclear antibody that is used to support diagnosis of CREST syndrome

A

Anticentromere antibody

38
Q

It is a limited form of scleroderma

A

CREST

39
Q

An antinuclear antibody that is used to support in diagnosis of the limited form of scleroderma

A

Anticentromere antibody

40
Q

the formation of tiny deposits of calcium in the skin

A

calcinosis

41
Q

a vasopastic disorder causing discoloration of the fingers, toes and other extremities

A

Raynaud’s syndrome

42
Q

Associated with the poor functioning muscle of the lower 2/3’s of the esophagus. It yield a wide opening of the esophageal tissue

A

esophageal dysmotility

43
Q

the localized thickening and tightness of the skin of the fingers and toes

A

sclerodactyly

44
Q

tiny red areas of the face, mouth, hands, mucous membranes ans even in the extremities; cause dilated capillaries that lead to extravasation of the RBC

A

telangiectasias

45
Q

Which of the ff. that causes the telangiectasias?
a. calcium deposits to the fingers, knees and elbows
b. dilated cappilaries in the surroundign connective tissues attacked by the Ab
c. thickening and tightness of the skin
d. vasospasm in the arterioles

A

b. dilated cappilaries in the surroundign connective tissues attacked by the Ab

46
Q

An antibody used primarily to aid in the diagnosis of the autoimmune chronic active hepatitis (CAH)

A

Anti Smooth muscle antibody

47
Q

t/f. ASMA is also used to diagnose SLE

A

true

48
Q

Which of the ff is true about CAH?
a. also referred as lupoid hepatitis
b. char. histologically by periportal necrosis and plasma infiltration in of the portacl tracts
c. Manifestation should exist over 5 months before it is considered as CAH
d. all of the above
e. 1 is true; 2 are false. Identify which
f. 2 are true; 1 is false. identify asa

A

f. only letter c is false kay 6 mos

49
Q

Type fo CAH where it is char. by the presence of ASMA, also has ANA and it the most prevalent

A

type 1 cah

50
Q

What type of CAH that is seen with othwr autoimmune diseases such as hyperthyroidism and Coomb’s positive hemolytic anemia

A

type 1

51
Q

What type of CAH that is char. by the presence of antiliver-kidney microsomal antibodies

A

type 2

52
Q

What type of CAH that is dominant to pediatric and associated to autoimmune disorder such as insulin-dependent diabetes and autoimmune thyroid disease

A

type 2 cah

53
Q

type of CAh that is char. by the presence of anti-soluble liver antigen (anti-SLA)

A

type 3 cah

54
Q

Antinuclear antibodies that are extracted from the nucleus of thr human B lymphocytes

A

anti ssa
anti ssb
anti ssc

55
Q

What pattern presents the La and Ro under uv microscope

A

speckled apttern

56
Q

It is used in the diagnosis of Sjogren’s syndrome. iodentify if it is for primary or secondary

A

Anti-La (more specific) and ANti-Ro for primary
Anti-SSC secondary

57
Q

An autoimmune disorder that affects the exocrine glands

A

Sjogren’s syndrome

58
Q

T/F. Secondary Sjogren’s is associated with autoimmune disease such as RA

A

true

59
Q

Enumerate the test used for Keratoconjuctivitis sicca

A

schirmer test
rose bengal test

60
Q

A test for KCS that is done without anesthesia. it measures the production of tears. If positive, wetness of the eye measures <5 mm for 5 minutes

A

schirmer test

61
Q

A test for KCS that uses a supravital stain that stains the cell or tissue of conjunnctivitis and cornea of the eye

A

rose bengal test

62
Q

What stain is used to stain the surface of the cornea and conjunctiva

A

rose bengal stain

63
Q

Rose bengal stain is not a flourescein stain but a derivative. It is derived from?

A

tetrachloro tetraiodo fluorescein dye

64
Q

What scoring system is used in Rose bengal test?

A

Van Bijsterveld’s scoring system

65
Q

A test that collects saliva and determine the volume of the salive produced in a 5 minute period

A

Salivary Function Test

66
Q

A lip tissue will reveal proliferation of lymphocytes/antibodies

A

lip biopsy

67
Q

it is used to assis in the diagnosis of SLE and MCTD. The antigen is extracted from the thymus

A

antiextractable nuclear antigen

68
Q

ANtibody that is sensitive to SLE

A

anti-smith

69
Q

antibody that is sensitive to MCTD

A

Anti-ribonucleoprotein

70
Q

Also referred as Fern TEst

A

cervical mucus

71
Q

It is used to indicate the timing ovulation and evaluation of infertility

A

cervical mucus

72
Q

It detects the ability for the cervical mucus to provide an optimal environment for the sperm cells to enter the fallopian tube

A

SIMS-HUHNER TEST

73
Q

It measures the ability of the sperm to penetrate mucus and maintain motility

A

sims-huhner

74
Q

T/F. LH and Estrogen is decreased in menstruation cycle esp. in the midcycle

A

false. decreased

75
Q

It is an abnormal dropping of the upper eyelid when the eyes of yhe px is looki g straight ahead

A

Blepharoptosis

Seminar 2 (3 decks)

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