Lesson 3

Question 1

when a vaccine is not available,

Answer 1

antiviral chemotherapy is necessary

Question 2

The other limiting factor in antiviral
chemotherapy is

Answer 2

The development of resistance.

Question 3

Classes of antiviral drugs

Answer 3

1. Immunomodulators:
2. Ion-channel blocking compounds
3. Neuraminadase inhibitors
4. Antiviral drugs which inhibit viral genome replication
5. Non-nucleoside polymerase inhibitors
6. Protease inhibitors

Question 4

It enhance innate immune responses, indirect antiviral effects
by inducing cytokines prominently interferons

Answer 4

Immunomodulators

Question 5

It prevents virus uncoating shortly after
endocytosis of virus by the host cell

Answer 5

Ion-channel blocking compounds

Question 6

interfere with release of virus from host cells

Answer 6

Neuraminadase inhibitors

Question 7

It is required to cleave sialic acid from the cell membrane of the
budding virions

Answer 7

Neuraminidase

Question 8

inhibit replication of viruses by binding
to the pyrophosphate binding site of the DNA polymerase to block binding of
nucleotides

Answer 8

Non-nucleoside polymerase inhibitors

Question 9

Protease inhibitors: used against HIV proteases
Examples

Answer 9

Saquinavir,
indinavir,
ritonavir,
nelfinavir; and
amprenavir

Question 10

It has antiviral activity against influenza A virus by
inhibiting an early step in the replication of the virus

Answer 10

Amantadine

Question 11

Example of neuraminidase inhibitor

Answer 11

Oseltamivir and Zanamivir (anti-influenza drugs)

Question 12

Example of Non-nucleoside polymerase inhibitors:

Answer 12

Foscarnet