Lesson 11 - Circadian Rhythms Flashcards
What is a circadian rhythm
Cycle which lasts 24 hours
What are circadian rhythms driven by
The suprachiasmatic nuclei (SCN) in the hypothalamus
What is the input that the SCN uses to reset circadian rhythms
- Natural light
* Process called photoentrainment
What are the three circadian rhythms
- Sleep-wake cycle
- Core body temperature
- Hormone production
When are the strongest sleep drives
- Between 02:00-04:00
* Between 13:00-15:00
How does light/darkness influence sleep
• Release of melatonin from pineal gland is at its peak during dark hours
• Melatonin induces sleep
-inhibits neural mechanisms that promote being awake
• Light suppresses melatonin production
What is the other influence sleep and wakefulness is controlled by
- Homeostatic control
- Homeostasis tells bodies that need for sleep increases longer awake for
- Energy used up when awake
How do circadian rhythms regulate sleep
Prompts bodies to sleep in dark
-wake when daylight
How does the homeostatic system regulate sleep
Makes us sleepier longer we have been awake
-regardless of night or day
How long is the internal circadian rhythm
24-25 hours regardless of natural light
+ Practical application of studying circadian rhythms
- Chronotherapeutics
- Time patients take meds is important
- Essential that right concentration of drug released in target area at right time of day
(-) Research conducted on circadian rhythms lack validity because of this oversight
- Conducted research has not isolated people from artificial light
- Was believed only natural light affected circadian rhythms
- Cziesler et al(1999) altered participant’s circadian rhythms down to 22 hours/up to 28 hours with artificial light
- There may be factors that vary which prevents general conclusions to be drawn
- Individual differences in circadian rhythms (1)
• Lengths of circadian rhythms found to vary
• From 13 to 165 hours
-Czeisler et al(1999)
• Suggests circadian rhythms may not be so timely
-understanding is not complete
- Individual differences in circadian rhythms (2)
The fact that some people are ‘morning’ and ‘evening’ people implies a difference in the sleep-wakefulness cycle
- Studies of individuals in Arctic regions
- The sun doesn’t set in summer
- Normal sleep patterns despite prolonged light exposure
- Suggests exogenous zeitgeber of light may have less bearing on internal biological rhythms than assumed