Lesson 1 Flashcards
Kind of controlled release
Delayed, pulsatile, extended, targeted, triggered
good candidates for DDS
short half-lives, poor bioavailability, periodic dosing, narrow therapeutic index
administration routes
parenteral, buccal, topical, ophthalmic, nasal, other (vaginal)
components of nanopharmaceuticals
drug and carrier
types of carrier
soluble macromolecule, micelles, nanoparticles, microparticles,lipoprotein,vesicles
types of capillary
no pores, fenestrated, sinusoidal
what to control in EPR effect
pressure, blood flow, reach the center of the tumor
immune system
innate & specific
opsonization
promotion of phagocytosis of antigens by macrophages and neutrophils, mediated by C3b
Mononuclear phagocyte system
monocytes, kupffer cells, alveolar macrophages, histiocytes
avoid MPS
coating with PEG
kind of targeting
active (chemical, physical) passive
benefits of vax
efficacious against diseases, mild reactions, risk smaller than natural disease, protection for oneself and the others
antigen delivery steps
uptake, transport, processing, presenting
crucial components of vax
particular form
immunostimulatory component
antigens
particulate format function
depot
recognition signal
carrier of antigens
modern delivery systems
virus-like particles virosomes iscoms nano/microparticles nanoemulsions IRIV
administrative routes
injection
transdermal
mucosal (nasal,oral,sublingual)
potential of new vax
protective, therapeutic,less sides, easier
risk of new vax
acute adverse effect
tolerance
unknow sustainability
