Lesions Of Necrosis Types Flashcards
Define coagulation necrosis.
The affected cells or tissue are converted into dry, dull, fairly homogenous tissue as a result of the coagulation of protein. (Grossly looks like seared meat…ewww!)
What is a classic example of coagulation necrosis in the kidney?
Renal infarct: pale or hemorrhagic infarct. Classical wedge-shaped infarct.
What type of pattern occurs in coagulation necrosis of the liver?
A zonal pattern. May also see pale, discrete Fock arranged throughout. Yellow coloration due to concurrent lipidosis (accumulation of lipid).
Necrosis characterized by a fairly well-circumscribed, visible lesion that contains purulent exudate, which is the remnant of tissue that became necrotic and was digested by proteolytic enzymes released from disintegrating neutrophils.
It’s classically observed in suppurations inflammation and abscesses.
-liquefactive necrosis (abscess)
What is a jowl abscess an example of?
Liquefactive necrosis. Jowl abscesses due to streptococcus infection of mandibular lymph nodes.
What type of necrosis is known to look “cheese like”?
Caseous necrosis!
Macrophage infiltrates into necrotic tissue INCOMPLETELY digest the dead tissue (as opposed to neutrophils that more more completely digest tissue into pus), affected tissue appears dry, crumbly, and dull (pale yellow)
-chronic granulomatous inflammations
What do low concentrations of proteolytic enzymes in macrophages cause?
Caseous necrosis, NOT liquefactive necrosis!
What type of necrosis involves death of tissue, usually in considerable mass, associated w/ loss of vascular (nutritive) supply and followed by anaerobic bacterial invasion and putrefaction?
Gangrenous necrosis
What is a state of decomposition that is accompanied by a foul odor? (Can be post-mortem)
Putrefaction
How cna gangrenous pneumonia occur?
Usually happens after aspiration of stomach contacts and accompanies anaerobic bacterial infection.
What is fat necrosis?
When fat cells die, neutral fats in the cells of adipose tissue are released and split into FA and glycerol, then mineralization and the deposition of chalky white deposits.
What is an ulcer?
Area of cutaneous or mucosal necrosis with sloughing of the necrotic tissues and exposure of underlying viable tissue.
When are skin ulcers often seen?
Overlying tumors or chronic inflammation in associated w/ viral, bacterial, or fungal infections, even in immune mediated skin diseases.
When do GI ulcers occur?
In chronic renal failure, non-steroidal anti-inflammatory drug treatment, certain bacteria infection like Helicobacter spp, viral infection, tumors, and stress.
What can be caused from an immune-mediated disease from antibodies against skin antigens?
An ulcer!
