Leshmania Flashcards

1
Q

Leshmania

A

Unicellular protozoa I’m 2 forms

  • Amastigote (non-motile, in mammals)
  • Promastigote (motile, in insect vector)
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2
Q

Vector

A

Sand fly (phlebotomus app)

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3
Q

Reservoir host

A

Dogs, other mammals and rodents

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4
Q

Leishmania causes

A

LEISHMANIASIS

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5
Q

Visceral leishmaniasis

A
L. Donovan - kalaazar
Travels to internal organs
- liver
- spleen 
- bone marrow
Leading to organomegaly (hepatosplenomegaly)

MOST SEVERE - fatal

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6
Q

Cutaneous leishmaniasis

A

L. Tropica

  • Enters phagocytes via receptor mediated phagocytosis
  • Establishes a parasitophorous Vacoule
  • Survives inside by delaying phagosome maturation
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