Leprosy Flashcards

1
Q

Causative Agent

A
  1. Myobacterium Leprae
  2. Myobacterium Lepromatesis

Gram - (Purple and Red) - Thin Pep

Gram + (Pink) - Thicker Pepticoglycan
Gram - (Purple and Red) - Thin Pep

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2
Q

Mode of Transmission

A
  1. Droplet
  2. Prolong skin to skin contact
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3
Q

Early Signs and Symptoms

A
  1. Change in skin color
  2. Lost of sensation/ Large and thicked peripheral nerve
  3. Lost of sweating
  4. Ulcers that do not heal
  5. Muscle Weakness
  6. Painful and Redened Eyes
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4
Q

Late Signs and Symptoms

A
  1. Madorosis - Loss of eyebrows
  2. Lagopthalmos - inability to close eyelids
  3. Sinking of the nose bridge
  4. Clawing of Fingers and toes
  5. Contructures - hardening & weakenning of the muscle
  6. Enlargement of Breast
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5
Q

Classification of Leprosy

A
  1. Paucibacilliary
    - Tuberculoid
    - Indeterminate
    - Not Infectious
  2. Multibacillary
    - Borderline
    - Lepromatus
    - Highly Infectious
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6
Q

Incubation

A

Paucibacilliary - 1-4 years (8 years)
Multibacilliary - 4-8 years (extended years)

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7
Q

Lesions

A

Paubacilliary - <5 lesions
Multibacilliary - >5 lesions

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8
Q

Bacilli

A

Paubacilliary - Few baccili (6-9 months of treatment)
Multibacilliary - More bacilli (24-30 months of treatment)

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9
Q

Diagnostic Test

A

Slit Skin Smear (Scrape lesion)

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10
Q

Medical Treatment

A

RA 4073 - Domiciliary Treatment of Leprosy

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11
Q

Treatment for Paucibacilliary (Adult)

Day 1

A

Rfampicin 600mg (Once a month)
Dapsone 100 mg (daily)

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12
Q

Treatment for Paucibacilliary (Adult)

Day 2 - 28

A

Dapsone 100mg
6 blister pack to be taken monthly within amaximun peroid of 9 months

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13
Q

Treatment for Multibacilliary (Adult)

Day 1

A

Rifampicin 600mg (once a month)
Dapsone 300 mg (once a month)
Clofamizine 100 mg (daily)

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14
Q

Treatment for Multibacilliary (Adult)

Day 2 - 28

A

Clofazimine 100mg
Dapsone 50 mg
12 blister packs to be taken monthly within maximum peroid of 18 months

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15
Q

Treatment for Paucibacilliary (Children)

Day 1

A

Rifampicin 450 mg
Depsone 50 mg

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16
Q

Treatment for Paucibacilliary (Children)

Day 2 - 28

A

Dapsone 50 mg

17
Q

Treatment for Multibacilliary (Children)

Day 1

A

Rifampicin 450 mg
Clofazimine 50 mg
Dapsone 150 mg

18
Q

Treatment for Multibacilliary (Children)

Day 2 -28

A

Clofazimine 50 mg
Dapsone 50 mg (every other day)

19
Q

Vaccine

A

BCG - 0.5 ml
- ID

fever and permanent scar

Dilute of sterile water 2-3 cc in 5 cc syringe
if na open na vaccine throw after 4 hours

20
Q

Prevention

A

Single dose of Rifampicin given to 2y/o and above