Leprosy Flashcards
Causative Agent
- Myobacterium Leprae
- Myobacterium Lepromatesis
Gram - (Purple and Red) - Thin Pep
Gram + (Pink) - Thicker Pepticoglycan
Gram - (Purple and Red) - Thin Pep
Mode of Transmission
- Droplet
- Prolong skin to skin contact
Early Signs and Symptoms
- Change in skin color
- Lost of sensation/ Large and thicked peripheral nerve
- Lost of sweating
- Ulcers that do not heal
- Muscle Weakness
- Painful and Redened Eyes
Late Signs and Symptoms
- Madorosis - Loss of eyebrows
- Lagopthalmos - inability to close eyelids
- Sinking of the nose bridge
- Clawing of Fingers and toes
- Contructures - hardening & weakenning of the muscle
- Enlargement of Breast
Classification of Leprosy
- Paucibacilliary
- Tuberculoid
- Indeterminate
- Not Infectious - Multibacillary
- Borderline
- Lepromatus
- Highly Infectious
Incubation
Paucibacilliary - 1-4 years (8 years)
Multibacilliary - 4-8 years (extended years)
Lesions
Paubacilliary - <5 lesions
Multibacilliary - >5 lesions
Bacilli
Paubacilliary - Few baccili (6-9 months of treatment)
Multibacilliary - More bacilli (24-30 months of treatment)
Diagnostic Test
Slit Skin Smear (Scrape lesion)
Medical Treatment
RA 4073 - Domiciliary Treatment of Leprosy
Treatment for Paucibacilliary (Adult)
Day 1
Rfampicin 600mg (Once a month)
Dapsone 100 mg (daily)
Treatment for Paucibacilliary (Adult)
Day 2 - 28
Dapsone 100mg
6 blister pack to be taken monthly within amaximun peroid of 9 months
Treatment for Multibacilliary (Adult)
Day 1
Rifampicin 600mg (once a month)
Dapsone 300 mg (once a month)
Clofamizine 100 mg (daily)
Treatment for Multibacilliary (Adult)
Day 2 - 28
Clofazimine 100mg
Dapsone 50 mg
12 blister packs to be taken monthly within maximum peroid of 18 months
Treatment for Paucibacilliary (Children)
Day 1
Rifampicin 450 mg
Depsone 50 mg
Treatment for Paucibacilliary (Children)
Day 2 - 28
Dapsone 50 mg
Treatment for Multibacilliary (Children)
Day 1
Rifampicin 450 mg
Clofazimine 50 mg
Dapsone 150 mg
Treatment for Multibacilliary (Children)
Day 2 -28
Clofazimine 50 mg
Dapsone 50 mg (every other day)
Vaccine
BCG - 0.5 ml
- ID
fever and permanent scar
Dilute of sterile water 2-3 cc in 5 cc syringe
if na open na vaccine throw after 4 hours
Prevention
Single dose of Rifampicin given to 2y/o and above