Lens and cataracts Flashcards
Lens capsule antioxdiants
contains glutathione and ascorbic acid
Lens capsule posterior
Thinnest
Doesnt thicken with age
Lens capsule anterior
Thickens with age
Lens capsule content
Collagen 4
Lens epithelium
single cuboidal cell layer
only found below anterior capsule
periphery - mitotic
central - non-mitotic
Lens sutures
Anteriro Y
Posterior inverted Y
Lens ultrastructure
Nucleus (old fibres)
Cortex (new fibres)
Cataract grades
Immature - partially opaque
Mature - completely opague
Hypermature - cataract material leaking, shrunk and winkly anterior capsule
Morgagnian cataract - cortex had liquified and nucleus has sunk in it
Age related Cataract types
Nuclear - centre yellow, myopic shift! near vision improves
Cortical - wedge shaped opacity, glare at night with bright lights
Subcapsular - anterior (blunt trauma), posterior (diabetes, chloroquine, steroids, retinitis pigmentosa, NF)
Polychromatic (christmas tree) - needle like opacities in nucleus and deep cortex
Cataract associations:
Anterior subcapsular
Blue dot
Pearly nuclear
Sunflower
Shield like
Christmas tree
Anterior subcapsular - blunt trauma
Blue dot - down syndrome
Pearly nuclear - Rubella
Sunflower - Wilson’s disease
Shield like - Atopic dermatitis
Christmas tree - myotonic dystrophy
Congenital cataracts
Autosomal dominant, also due to homocystinuria and Down syndrome
Unilateral - remove at 6 weeks
Bilateral - remove at 10 weeks
Weigh risk between glaucoma and amblyopia
Biometry
Calculating IOL power - IOLmaster
Parameters:
Axial length of the eye, corneal curvature, anterior chamber depth
Types of IOL
Rigid - PMMA, not widely used
Soft -
1. Silicon - not used
2. Acrylic hydrophobic - less risk of PCO but glare
3. Acrlylic hydrophilic - high biocompatibility but risk of PCO
Techniques of cataract surgery
- Phacoemulsification (gold standard) - US needle
- extracapsular cataract extraction (ECCE) - wide incision, good for rigid cataracts
Phacoemulsification procedure
Intraoperative complications of cataract surgery
- Posterior capsule rupture
- Floppy iris syndrome (when pt on tamsulosin)
- Choroidal haemorrhage!!
- Dropped nucleus (nucleus fragments escape the capsule)
Post operative complications of cataract surgery
Early : corneal oedema, elevated IOP, endophthalmitis (1 week)
Late : PCO (most common), Irvine-Gass syndrome (cystoid macula oedema), retinal detachment, delayed endophthalmitis
Endophthalmitis prevention
Providone iodine before operation
Endophthalmitis features
vitritis (floaters and blurred vision), hypopyon, pain, corneal haze
Endophthalmitis mx
Intravitreal abx
vitrectomy
Endophthalmitis types
Acute - 1 week, staph epidermidis
Delayed - upto 6 weeks, propionibacterium acne
Post trauma - staph or bacillus cereus
fungal - candida
Posterior capsule opacification
Most common delayed complication
Blurred vision, as if cataract has returned
Mx: Nd:YAG capsulotomy
Secondary causes of congenital cataracts
Galactosaemia (AR)
Fabry disease (XLR)
Lowe syndrome (XLR)
Down syndrome
Congenital Rubella
Lenticonus
Cone like protrusion of lens
Anterior lenticonus - Alport syndrome
Posterior lenticonus - Lowe syndrome
Lentiglobus
Hemispherical protrusion of the lens
Ectopia lentis
lens displacement
What is the direction of displacement in these:
Familial ectopia lentis
Marfan’s syndrome
Homocystinuria
Weill-Marchesani syndrome
Familial - superotemporal (f)
Marfan - superotemporal (f)
Homocystinuria - inferonasal (y)
Weill Marchesani - anterior inferior
Congenital aphakia
born without lens, FOX3 mutation
U+D=V
U → vergence of light entering the lens (object rays)
D → vergence added to light by the lens (lens power)
V → vergence of light leaving the lens (image rays)
Image by minus (biconcave) lens is …..
always virtual, erect and diminished
Image by plus (biconvex) lens is
Snellen chart
6 stays on top!
LogMAR chart
0-1
0 normal vision
1 6/60 vision
each letter 0.02, subtrated from 1
Duochrome test
Red - longer wavelength, image forms behind retina
Green - shorter wavelength, image forms in front of retina
Retinoscopy
Objective measure of visual acuity
myopia - red reflex moves against direction of light
Hypermetropia - red reflex moves with the direction of light