Lens Flashcards

1
Q

What is the function of the lens?

A

Responsible for fine-tuning an image that is projected onto the retina.

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2
Q

What does the lens need to be functional?

A

Needs to be transparent,
Have a higher refractive index than the medium its suspended in,
Have flexible refractive surfaces with the proper curvature

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3
Q

What two types of epithelial cells make up the lens?

A

cubodial cells and elongated fiber cells

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4
Q

what do the epithelial cells of the lens secrete?

A

the lens capsule

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5
Q

What is the germanitive zone?

A

Region near the equatorial margin of the lens epithelium, where cells proliferate slowly.

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6
Q

True or False. Posterior Y sutures are upright.

A

False. posterior = inverted Y, anterior = upright Y

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7
Q

Where do the zonules originate?

A

Non-pigmented layer of the ciliary epithelium

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8
Q

Where do the zonules insert?

A

Lens capsule near the equator

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9
Q

How much crystallin does the lens have compared to typical cells?

A

3x higher

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10
Q

what allows for transparency of the lens?

A

Regular structure of lens fibers,
The absence of membrane-bound organelles,
Small/uniform extracellular space between fiber cells

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11
Q

True or False. Aphakia is the substitution of the natural crystalline lens with a synthetic lens.

A

False.
Aphakia: is the absence of the natural crystalline lens, from natural causes or removal.

Pseudophakia: is the substitution of the natural crystalline lens with a synthetic lens.

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12
Q

What is the role of the α-crystallin genes , αA and αB?

A

Prevent protein aggregation and precipitation

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13
Q

What percent of the lens is made of water?

A

65% water

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14
Q

What gives lens its birefringent property?

A

microtubules

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15
Q

What effect does increased cholesterol have on fibers?

A

Makes it more rigid.

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16
Q

Where did the capillaries at the ANTERIOR part of the lens arise from during development?

A

Arise from blood vessels of the iris stroma

17
Q

Where did the capillaries at the POSTERIOR part of the lens arise from during development?

A

Arise from the hyaloid artery

18
Q

What can an absences of lens in early embryogenesis lead to?

A

Absence of corneal endothelium,
Abnormal differentiation of the corneal stroma,
Absence of the iris, ciliary body, and anterior chamber

19
Q

What protects the lens protects it from oxidative damage?

A

The low oxygen tension around/within the lens

20
Q

What process generates free radicals in the lens?

A

oxidative phosphorylation

21
Q

True or False. If light is not absorbed, it produces no damage.

A

True.