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Rheumatoid Arthritis > Leflunomide (DMARD) > Flashcards

Leflunomide (DMARD) Flashcards

1
Q

MoA

A

Dihydroorotate dehydrogenase
Antagonist
Blocks pyrimidine production
Blocks clonal expansion of T-cells

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2
Q

Indications

A

2nd Line DMARD

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3
Q

ADR

A

Anaemia
Hepatotoxicity
Diarrhoea
Nausea

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4
Q

Prescribing Advice

A

X Pregnancy/Lactating

Needs 2 year washout period

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Rheumatoid Arthritis (6 decks)

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