Lectures 7-9

Question 1

How was a Schizophrenia model made in rats and what drugs are used to treat it?

Answer 1

Using amphetamines, a Schizophrenia model can be established in rats.

Question 2

What are 3 drugs that are used to treat Schizophrenia and how do they work?

Answer 2

Drugs block actions of dopamine:

Chlorpromazine
Haloperidol
Pimozide

Question 3

How was a Parkinson’s disease model established?

Answer 3

MPTP is taken up by cells where it becomes MPP+.

MPP+ destroys nerves resulting in Parkinson’s disease.

Question 4

How was a vomiting model established in ferrets and what drugs have been made from the model?

Answer 4

Cisplatin induces vomiting (emesis) in ferrets.

This has been use to develop anti-emetics such as, ondansetron.

Question 5

How has a Rheumatoid arthritis model been established in rats?

Answer 5

Model is made by injecting Freund’s adjuvant - a mixture of killed M/ tuberculosis and liquid paraffin.

Question 6

How has a model of myocardial infarction (heart attack) been made in rats?

Answer 6

A heart attack model can be established by tying the coronary artery of an anaesthetised animal.

Question 7

How has a model of diabetes been made in rats?

Answer 7

Injecting the rat with Streptozotocin will result in the death of the rat’s β-cells