Lectures 23 to 26 - Reproduction Flashcards
Final Exam Prep
Define ‘corona radiata’
The innermost layer of granulosa cells that is firmly attached to the zona pellucida around a secondary oocyte.
Define ‘cumulus oophorus’
A mass of epithelial granulosa cells surrounding the oocyte in the maturing ovarian follicle.
Define ‘gamete’
A male or female reproductive cell; a sperm cell or secondary oocyte.
Define ‘fertilization’
Penetration of a secondary oocyte by a sperm cell, meiotic division of a secondary oocyte to form an ovum, and subsequent union of the nuclei of the gametes.
Define ‘oogenesis’
Formation and development of female gametes (oocytes).
Define ‘ovarian cycle’
The normal sex cycle of the ovaries that includes: 1) the follicular phase - development of an ovarian (graafian) follicle 2) ovulation - rupture of the follicle with discharge of the ovum 3) the luteal phase - formation and regression of a corpus luteum.
Define ‘menstrual cycle’
The period in which an ovum matures, is ovulated, and enters the uterine lumen through the fallopian tubes; ovarian hormonal secretions effect endometrial changes in preparation for fertilization and implantation; in the absence of fertilization, ovarian secretions wane, the endometrium sloughs, and menstruation begins. This cycle lasts an average of 28 days, with day 1 of the cycle designated as that day on which menstrual flow begins.
Define ‘ovulation’
The rupture of a mature ovarian (graafian) follicle with discharge of a secondary oocyte into the pelvic cavity.
Define ‘sperm’
A mature male gamete. Also termed spermatozoon
Define ‘oogonium’
A diploid stem cell that arises from a primordial germ cell and differentiates into an oocyte in the ovary.
Define ‘chromosome’
One of the small, threadlike structures in the nucleus of a cell, normally 46 in a human diploid cell, that bears the genetic material. Composed of DNA and proteins (histones) that form a delicate chromatin thread during interphase; becomes packaged into compact rodlike structures that are visible under the light microscope during cell division.
Define ‘meiosis’
A type of cell division that occurs during production of gametes, involving two successive nuclear divisions that result in cells with the haploid (n) number of chromosomes.
Define ‘puberty’
The time of life during which the secondary sex characteristics begin to appear and the capability for sexual reproduction is possible; usually occurs between the ages of 10 and 17.
Define ‘primary oocyte’
An oocyte during its growth phase and before it completes the first meiotic division.
Define ‘secondary oocyte’
An oocyte in which the first meiotic division is completed; the second meiotic division usually stops short of completion unless fertilization occurs.
Define ‘primary ovarian follicle’
An immature follicle consisting of the oocyte surrounded by a single layer of tall supporting (granulosa) cells.
Define ‘ovary’
Female gonad that produces oocytes and the estrogen, progesterone, inhibin, and relaxin hormones.
Define ‘follicular phase’
The portion of the menstrual cycle in which the ovarian follicle develops and matures. This half of the menstrual cycle begins on the first day of menses and ends with ovulation. The follicular phase is characterized by a gradual rise in the steroid hormone estrogen.
Define ‘luteal phase’
The portion of the menstrual cycle in which the corpus luteum forms and matures. This half of the menstrual cycle begins with ovulation and ends when menstruation begins. The luteal phase is characterized by a gradual rise in the steroid hormone progesterone.
Define ‘corpus luteum’
A yellowish body in the ovary formed when a follicle has discharged its secondary oocyte; secretes estrogens, progesterone, relaxin, and inhibin.
Define ‘follicle’
A small secretory sac or cavity; the group of cells that contains a developing oocyte in the ovaries.
Define ‘progesterone’
A female sex hormone produced by the ovaries that helps prepare the endometrium of the uterus for implantation of a fertilized ovum and the mammary glands for milk secretion.
Define ‘uterus’
The hollow, muscular organ in females that is the site of menstruation, implantation, development of the fetus, and labor.
Define ‘endometrium’
The mucous membrane comprising the inner layer of the uterine wall; it consists of a simple columnar epithelium and a lamina propria that contains simple tubular uterine glands.
Define ‘granulosa cells’
Somatic cells that surround the oocyte, providing it with the physical support and nutrients needs for proper oocyte development.
Define ‘secondary ovarian follicle’
A maturing ovarian follicle consisting of the oocyte surrounded by two or more layers of tall supporting (granulosa) cells.
Define ‘mature follicle’
The most mature ovarian follicle stage. Characterized by its large diameter and the presence of a liquid-filled space, or antrum, containing a secondary oocyte and surrounding granulosa cells that secrete estrogens. Also called an antral, Graafian, or vesicular follicle.
Define ‘primordial follicle’
The most immature stage of ovarian follicle development. The primordial follicle consists of the oocyte surrounded by a single layer of flat supporting (granulosa) cells.
Define ‘zona pellucida’
Clear glycoprotein layer between a secondary oocyte and the surrounding granulosa cells of the corona radiata; important in inducing the acrosome reaction during fertilization and preventing polyspermy.
Define ‘follicular antrum’
The portion of an ovarian follicle filled with liquor folliculi. Appearance of the follicular antrum during follicular maturation is the first sign that a follicle has reached the next stage of maturation, changing from a primary follicle to a secondary follicle.
Define ‘polar body’
The product of asymmetric cell division that occurs during meiosis. Both phases of meiosis produce a polar body, and the final result of completed meiosis is two polar bodies and one haploid egg.
Define ‘estrogens’
Female steroid sex hormones produced by the ovaries and, in small amounts, in the adrenal cortex, male testes, and the placenta; govern development of oocytes, maintenance of female reproductive structures, and appearance of secondary sex characteristics; also affect fluid and electrolyte balance, and protein anabolism. Examples are beta-estradiol, estrone, and estriol.
Define ‘hypothalamus’
A portion of the diencephalon, lying beneath the thalamus and forming the floor and part of the wall of the third ventricle.
Define ‘GnRH - gonadotrophin releasing hormone’
A hormone secreted in pulses by the hypothalamus, which stimulates the synthesis of gonadotrophins by the pituitary gland.
Define ‘FSH - follicle stimulating hormone’
A gonadotropin secreted by the anterior pituitary; it initiates development of ova and stimulates the ovaries to secrete estrogens in females, and initiates sperm production in males.
Define ‘LH - luteinizing hormone’
A gonadotropin secreted by the anterior pituitary that stimulates ovulation, stimulates progesterone secretion by the corpus luteum, and readies the mammary glands for milk secretion in females; stimulates testosterone secretion by the testes in males.
Define ‘pituitary gland’
A small endocrine gland occupying the hypophyseal fossa of the sphenoid bone and attached to the hypothalamus by the infundibulum; responds to signals from the hypothalamus to produce and release hormones that control other organs and body processes; responds to signals from the hypothalamus. The anterior pituitary secretes hormones that control physiological processes including growth, reproduction and stress. The posterior pituitary secretes hormones involves with water balance and uterine contractions during labor.
Define ‘stratum functionalis’
The stratum compactum and stratum spongiosum combine to make up this layer of the endometrium next to the uterine cavity that is shed during menstruation and that forms the maternal portion of the placenta during gestation.
Define ‘uterine glands’
The epithelial glandular compartment of the endometrium, which is contiguous with the luminal epithelium. The glands synthesise and secrete most of the protein and other components of uterine fluid (histotroph). Glandular secretions are necessary for embryo implantation.
Define ‘stratum basalis’
The layer of the endometrium next to the myometrium that is maintained during menstruation and gestation and produces a new stratum functionalis following menstruation or parturition.
Define ‘myometrium’
The smooth muscle layer of the uterus.
Define ‘endometrial stroma’
The connective tissue that forms the foundation, or framework of the uterus.