Lectures 19: Adverse Drug Reactions

Question 1

Type A (Augmented) ADR: Bradycardia with β-adrenoceptor antagonists

Answer 1

Atenolol

Question 2

Type E (End-of treatment) ADR:
Known as withdrawal effects
e.g. Development of angina (chest pain) if β- adrenoceptor antagonists are suddenly stopped.

Answer 2

(Atenolol)

Question 3

Type A (Augmented) ADR:
Dry skin, constipation

Answer 3

Atropine

Question 4

Type A (Augmented) ADR:
Hypoglycemia

Answer 4

Insulin

Question 5

Type B (Bizarre) ADR:
IMMUNOGENIC (drugs or their metabolites can bind to tissue proteins to form immunogens)

Answer 5

Penicillins

Question 6

Skin reactions, anaphylactic shock

Answer 6

Penicillins

Question 7

Type B (Bizarre) ADR:
Genetic

Answer 7

Suxamethonium

Question 8

Patients with abnormal plasma cholinesterase enzyme are unable to develop prolonged paralysis and apnea.

Answer 8

Suxamethonium

Question 9

Type B (Bizarre) ADR:
Genetic

Answer 9

Primiquine

Question 10

• Patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD) may develop hemolytic anemia as a result of administering oxidants drugs
• This deficiency is common in black males (10%) and mediterraneans.

Answer 10

Primiquine