Lectures 1-5 Flashcards
What are the general benefits of S&C?
Helps prevent injury Promotes healthy bones Improved posture Increased fitness Increase metabolism Psychological well-being
What are the athletic benefits of S&C?
Faster
Stronger
More mobile
What is muscular strength?
Muscles ability to exert force (on slides)
The maximum amount of force that a muscle can exert against some form of resistance in a single effort (google)
What is muscular endurance?
Sustained successive exertions (on slides)
The ability of a muscle or group of muscles to sustain repeated muscular contraction against a resistance for a prolonged period of time (google)
What is muscular power?
Ability to exert force per unit of time (e.g., rate of force development)
The ability to exert a maximal force in as short a time as possible
The proportion of people aged 60 and over is growing
Between 1970 and 2025, what is the predicted growth in older populations?
In 2025, how many people will be aged 60 and over?
(Ageing populations)
870 million / 380%
1.2 billion
Definition of ageing?
Ageing populations
The process of growing old
What is ageing?
Ageing populations
Complex and multidimensional phenomenon
Manifested differently between individuals throughout the lifespan
Highly conditional on interactions between genetic, environmental, behavioural, an demographic characteristics
Even with healthy ageing (ageing in the absence of disease), what can ageing lead to?
(Ageing populations)
Reductions in physiological resilience, often leading to:
Physical disability Mobility impairment Falls Decreased independence Decreased quality of life
What is ageing associated with in terms of skeletal muscle mass?
What is this called?
(Ageing populations)
A decline in skeletal muscle mass and muscle strength
Sarcopenia
What is the age-related loss of muscle mass related to?
Ageing populations
The loss of innervating motor neurone and denervation of muscle fibres
Anatomical counts estimate what loss in motor neurons in upper and lower limbs?
How many muscle fibres to each of these neurons innervate?
(Ageing populations)
Upper: 35000 (Gesslbauer et al. 2017)
Lower: 60000 (Tomlinson & Irving, 1977)
each neuron innervates hundreds or thousands of muscle fibres
What may happen if a motor neuron is impaired or degraded during ageing?
(Ageing populations)
It’s muscle fibres may lose their innervation and will be vulnerable to apoptosis
What is apoptosis?
Ageing populations
The death of cells which occurs as a normal and controlled part of an organism’s growth or development
Observational studies indicate what percentage of muscle mass is lost per year after the fourth decade of life?
(Ageing populations)
1%
What is the prevalence of Sarcopenia in:
Adults older than 60 years?
Adults older than 80 years?
(Ageing populations)
10%
50%
What is sarcopenia part of?
Ageing populations
The causal pathway for strength loss, disability, and morbidity in older adult populations
What is sarcopenia?
Ageing populations
The loss of skeletal muscle mass and strength as a result of ageing
What does evidence (Slide 13, lecture 2) link muscular weakness to?
(Ageing populations)
Diabetes Disability Cognitive decline Osteoporosis Changes in dynamic balance Movement coordination Early mortality
What must key strategies be with ageing populations?
Ageing populations
Preserving muscle mass which we lose with age
Strengthening bones to prevent osteoporosis
What is the NCSA position with helping ageing populations?
Ageing populations
Current research has demonstrated that countering muscle disuse through resistance training is a powerful intervention to combat muscle strength loss, sarcopenia and frailty
What has poor physical performance been shown to predict?
Ageing populations
Disability
Nursing home admission
Mortality
In community-dwelling older adults
What do strength and rate of change of strength contribute to?
(Ageing populations)
The impact of sarcopenia on mortality
What is muscular strength inversely and independently associated with?
(Ageing populations)
Death from all causes and cancer in men, even after adjusting for cardiorespiratory fitness and other potential cofounders
What percentage of people 65+ have sarcopenia?
How many Europeans are projected to have sarcopenia in 2045?
Ethgen et al. 2017
(Ageing populations)
10-20%
20-30 million
UK physical activity guidelines (adults and older adults), in terms of strength
(Ageing populations)
“To keep muscles, bones and joints strong”
Build strength on at least two days a week (e.g., resistance training, yoga etc)
UK physical activity guidelines (adults and older adults), in terms of duration of exercise
(Ageing populations)
At least 150 mins moderate intensity per week (E.g., swim, brisk walk, cycle)
Or
At least 75 mins vigorous intensity per week (e.g., run, stairs, sport)
UK physical activity guidelines (adults and older adults), other attempts that should be made
(Ageing populations)
Minimise sedentary time
Improve balance (for older adults to reduce chance of frailty and falls) (2 days a week)
What are the benefits of strength training?
Ageing populations
Increased muscle and bone mass, muscle strength, flexibility, dynamic balance, self-confidence, and self-esteem
Helps reduce symptoms of various chronic diseases such as arthritis, depression, type-2 diabetes, osteoporosis, sleep disorders and heart disease
In addition research (lecture 2, slide 18) demonstrates that strength training in older adults with functional limitations reduces falls
Despite known benefits of resistance training, only X% of older adults (75+ years) in US participate in muscle-strengthening activities as part of their leisure time (Fragala et al. 2019)
(Ageing populations)
8.7%
Reported barriers to participation in resistance exercise for older adults include:
(Ageing populations)
Safety Fear Health concerns Pain Fatigue Lack of social support
What is the evidence-based prescription? (Slide 21, lecture 2)
(Ageing populations)
Regular (2-3 days per week), intensity (70-85% of 1RM), volume (2-3 sets per exercise) of 1-2 multijoint exercises per major muscle group
With a periodised approach, resistance exercise results in what?
(Evidence-based prescription)
(Ageing populations)
Favourable neuromuscular adaptation in both health older adults and those with chronic conditions
Improve balance, preserve bone density, independence, reduce risk of numerous chronic diseases such as heart disease, arthritis
Favourable neuromuscular adaptation translate to what?
Ageing populations
Functional improvements of daily living activities, especially when power training exercise is included
Cautions with resistance training in older adults?
Ageing populations
Engaging in resistance exercise performed until exhaustion will increase blood pressure, HR and Q
Frailty in people older than 65 is high
Mobility limitations
Obesity
Classification of muscular tissue:
Cardiac muscle
(Muscle structure function lecture)
Striated
Branched cells
1-3 central nuclei
Involuntary
Classification of muscular tissue:
Skeletal muscle
(Muscle structure function lecture)
Striated
Elongated cells
Multinucleated cells
Voluntary
Classification of Muscular Tissue:
Smooth muscle
(Muscle structure function lecture)
Nonstriated
Single central nucleus
Involuntary
How many muscles in the human body?
Muscle structure function lecture
~660 skeletal muscle in human body
What % of total bodyweight is muscle mass
Muscle structure function lecture
40-45%
What are the largest cells in the body?
Muscle structure function lecture
Skeletal muscle fibres
How are skeletal muscle fibres created?
Muscle structure function lecture
By the fusion of many individual embryonic muscle cells
Mechanical roles of skeletal muscle
Muscle structure function lecture
Generate force Maintain posture Produce movement Maintain health Independence
Metabolic roles of skeletal muscle
Muscle structure function lecture
Basal energy production
Storage for amino acids and CHO
Production of heat
Consumption of oxygen and fuel for physical activity & exercise
Factors that influence muscle actions responsible for force generation
(Muscle structure function lecture)
Structure and architecture
Fiber types
Excitation-contraction coupling
Energy release
Slide 7, lecture 3 for diagram of muscle structure
Muscle structure function lecture
Important
Connective tissues:
Epimysium
(Muscle structure function lecture)
Is the fibrous tissue envelope that surrounds skeletal muscle
Connective tissues:
Perimysium
(Muscle structure function lecture)
Is a sheath of connective tissue that groups muscle fibres into bundles (anywhere between 10 and 100 or more) or fascicles
Connective tissues:
Endomysium
(Muscle structure function lecture)
Wispy later of areolar connective tissue that ensheaths each individual myocyte (muscle fibre, or muscle cell).
It also contain capillaries and nerves
Make up of a muscle fibre
Lecture 3, slide 9
(Muscle structure function lecture)
Important
Probably recap as well
What is the thin filament?
Muscle structure function lecture
Actin
What is the thick filament?
Muscle structure function lecture
Myosin
What is myosin (thick filament)
Muscle structure function lecture
A motor protein with the ability to create movement
What does each myosin contain?
And what is this?
(Muscle structure function lecture)
A smaller light chain & heavy chain
The motor domain
Which bit of myosin binds to ATP?
Muscle structure function lecture
The heavy chain
Why does the heavy chain of myosin bind to ATP?
Muscle structure function lecture
Because the motor domain acts as an enzyme
It is considered a myosin ATPase
The heavy chain also contains a binding site for actin
What is actin? (Thin filament)
Muscle structure function lecture
A globular protein which polymerise to form long chains or filaments, called F-actin
Actin contains how many regulatory proteins?
What are they called?
(Muscle structure function lecture)
Two
Troponin & tropomyosin
What do troponin and tropomyosin control?
Muscle structure function lecture
The interaction between actin and myosin
Where is troponin positioned?
What does it play a vital role in?
(Muscle structure function lecture)
Every 7 actin molecules
Plays a vital role in calcium reception
Where is tropomyosin positioned?
What is its main function?
(Muscle structure function lecture)
Distributed along the length of the actin filament, in the groove between 2 F-actin strands
Main function is to inhibit the coupling between actin and myosin
What do stochastic interactions of actin and myosin mean?
Muscle structure function lecture
That all sites aren’t bound
What % of crossbridges are formed in an isometric contraction?
(Muscle structure function lecture)
~30%
The cross bridge model is good for predicting what?
And not good for predicting what?
(Muscle structure function lecture)
Isometric and concentric forces
But not eccentric contractions
What is Titin?
Muscle structure function lecture
A 3rd contractile protein? (Slide 23 lecture 3)
What is Titin?
What does it do?
(Muscle structure function lecture)
A huge elastic molecule and the largest known protein, composed of more than 25,000 amino acids
It connects the Z line to the neighbouring M line
What are the multiple roles of Titin?
Muscle structure function lecture
Stabilises the position of the contractile filaments
Prevents overstretching of sarcomere
It’s elasticity returns stretched muscles to their resting length
It also has a very important role in eccentric force production - as a third force regulating myofilament in sarcomere
The Titin spring can also trigger mechanical signalling events in the myocytes leading to: enhances muscle protein degradation and activation of protein synthesis
Recap Titin slides in lecture 3
Muscle structure function lecture
Important
Titin has an emerging role in muscle function:
What does it do during muscle relaxation?
What does it do during muscle contraction?
What does this suggest ATP-driven motors also act as?
(Muscle structure function lecture)
It unwinds during relaxation
And folds during contraction
Latches, allowing Titin to fold, providing a powerful boost to muscle contraction
What is nebulin?
Muscle structure function lecture
It is an inelastic giant protein that lies alongside thin filaments and attaches to the Z disk
What are the proposed roles of Nebulin?
Muscle structure function lecture
Helps align the actin filaments of the sarcomere
Regulated actin-myosin interactions by inhibiting ATPase activity in a calcium-calmodulin sensitive manner
What are cytoskeletal proteins
Muscle structure function lecture
A number of other proteins found in interior of a muscle fibre and in sarcomeres
What are the roles of cytoskeletal proteins?
Muscle structure function lecture
Provide structural integrity
Allow lateral force transmission to adjacent sarcomeres
Connect myofibrils to cell membrane
Examples of cytoskeletal proteins
Muscle structure function lecture
Vinculin
Alpha and beta integrins
Dystrophin
Alpha-actinin
C-protein
Desmin
Where are satellite cells located? And what are they like?
Muscle structure function lecture
Adult skeletal muscle
Are stem-like cells
Where are satellite cells located?
Muscle structure function lecture
Between basement membrane and plasma membrane
What are satellite cells?
Muscle structure function lecture
Undifferentiated myoglobin precursors that have self-renewal properties
What happens when satellite cells are activated by myogenic factors?
(Muscle structure function lecture)
Satellite cells proliferate and differentiate into new muscle fibres
Recap questions
Muscle structure function lecture
Slide 29, lecture 3
Crucial
Where are the longest muscle cells/fibres in the body?
Muscle structure function lecture
The legs
Where are the smallest muscle cells/fibres in the body?
Muscle structure function lecture
Inner ear
What is found in the myofibril?
Muscle structure function lecture
Actin & Myosin
How many myofibrils can be in the muscle fibre?
Muscle structure function lecture
100,000s
What is the muscle fibre wrapped in?
Muscle structure function lecture
Endomysium
What is a sarcomere?
Muscle structure function lecture
Functional unit of the muscle
Made up of thick (myosin) and thin (actin) filaments
How are sarcomeres bound?
What is found in the middle of this?
(Muscle structure function lecture)
By a Z disc
The M line