Lectures 1-4 Flashcards
intracellular fluid
fluid inside cells (~67% body fluid)
extracellular fluid
body fluid outside cells
1/4 plasma
3/4 interstitial fluid
sensory/afferent component
- part of the nervous system that monitors internal and external environment
processing component
- part of the nervous system that integrates sensory input
efferent/motor component
- part of the nervous system that executes responses to stimuli
neuron
- fundamental unit of the nervous system
- composed of dendrites, cell body, and axons
glial cells
- non-neuronal cells of the nervous system
- mainly functions in support for neurons
astrocytes
- type of glial cell
- “scaffold” neurons
- help establish the blood-brain barrier
microglia
- type of glial cell
- immune support for the nervous system
oligodendrocytes
- type of glial cells
- creates myelin sheath to insulate axons + improve efficiency/speed of action potential propagation
ependymal cells
- type of glial cell
- epithelial cell in the nervous system (ventricles & spinal cord)
unipolar neuron
- afferent nervous system
- one dendritic end
- axon terminal synapses on neurons in the CNS
multipolar neuron
- multiple dendrites
- central & efferent nervous system
- axons synapse on other neurons or on effector cells
intracellular Na+ concentration
15 mM
Intracellular K+ concentration
150 mM
Extracellular Na+ concentration
145 mM
Extracellular K+ concentration
5 mM
neuronal resting membrane potential (RMP)
-70 mV
excitability
- refers to a cell’s ability to change its membrane potential
equilibrium potential
- concentration for a specific ion at which force of the membrane potential is equal in magnitude (but opposite in direction) to the ion’s concentration gradient
K+ equilibrium potention
-90mV
Na+ equilibrium potential
+60mV
action potential
- large, rapid change in membrane potential
depolarization
- increase in positive ions in the cell causes membrane potential to become less negative
hyperpolarization
- change in membrane potential that causes the cell to become more negative
absolute refractory period
- refractory period during the action potential, wherein another action potential cannot be generated
relative refractory period
- refractory period during late repolarization
- action potential can be generated, but requires more stimulus and is reduced in magnitude
saltatory conduction
- action potential conduction in which the potential “jumps” from one interruption in the myelin coating to the next
nodes of ranvier
- areas (in the central nervous system) where the myelin sheath coating axons is interrupted
- facilitates saltatory conduction