Lecture3: Antibodies

Question 1

Phosphotidylserine

Answer 1

Maintained inside the lymphocyte internally, the expressed on the exterior to attract phagocytes, the lymphocyte dies soon after activation

Question 2

Immunogenicity

Answer 2

The property of a molecule that lets it elicit an immune response. Immunogenicity is increased when the molecule is injected with an adjuvant which prolongs the molecules retention in the body so a more vigorous immune response can occur. (Alum, mineral oil, and lipids)

Question 3

Antigenicity

Answer 3

The property of a molecule that allows it to react with an antibody, used loosely to describe immunogens

Question 4

Haptens

Answer 4

Small molecules that cannot induce antibody formation but can react with antibody that is specific for it. It must be coupled to a carrier molecule in order to induce antibody formation. Therefore a happen is an antigen , but not an immmunogen

Question 5

Immunogens

Answer 5

Size >10,000 mw
Internal complexity: the more complex, the better capable to be an immunogen
Degradability: immunogen processing occurs in phag. So that the immunogen can be presented to T helper lymphocytes in conjunction with major histocompatibility proteins.
Foreigness: important to get the immune system to respond
Accessibility: exposed immunogens are more likely to elicit an immune response. Immunodominant areas.