Lecture Phases of Healing and Swelling Flashcards
Name the 3 phases of healing
- inflammatory (acute phase, protection phase) - proliferative (subacute, controled motion phase) - remodeling (chronic, return-to-function phase)
when does each phase of healing occur?
- inflammatory (first 2-3 days - 10 days) - proliferative (day 3 - week 3-6) - remodeling (day 9 - week 6-month12)
describe the repair process for most vascularized soft tissues
- similar process as described in lecture - time courses may vary - based on different tissue types
what are satellite cells?
-Satellite cells are precursors to skeletal muscle cells, able to give rise to satellite cells or differentiated skeletal muscle cells
what are schwann cells?
-any of the cells in the peripheral nervous system that produce the myelin sheath around neuronal axons.
describe the chart for post-injury strength
what are the 5 cardinal signs of inflamation?
what does the inflammatory response depend on?
–Size of injury
–Type of injury
–Tissue involved
–Vascularity of tissue involved
what is the physiological role of the inflammatory response? - describe beginning middle and end (4 processes involved)
describe the hemostatic response (inflam. phase)
Role:
–Control blood loss when vessels are ruptured
Process:
–Small blood vessels retract to seal themselves
–Fibrin clot formation
–Platelets aggregate and deposit fibrin to trap red blood cells and form a blood clot
describe the vascular response
describe the cellular response of the inflamatory phase
Initial response: Migration of leukocytes (white blood cells) to site of injury
Early inflammation: Neutrophils are dominant: removal of contaminating bacteria and debris (phagocytosis)
Late inflammation (within a few hours after injury):
–Macrophages (from monocytes) are dominant: phagocytosis and promotion of fibroblastic activity
–Lymphocytes: supply antibodies for specific antigens
what are leukocytes?
white blood cells
what are neutrophils?
a type of white blood cell - remove contaminating bacteria and debris (phagocytosis)
what are Macrophages
a type of white blood cell that engulfs and digests cellular debris
what are fibroblasts?
A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen.
Together, this extracellular matrix and collagen form the structural framework of tissues in animals and plays an important role in tissue repair.
what are lymphocytes
a type of white blood cell found in lymph
what are endothelial cells
lines the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.