Lecture one: pharmodynamics

Question 1

define pharmodynamics

Answer 1

what the drug does to the body

Question 2

define pharmokenetics

Answer 2

what the body does to the drug

Question 3

to properly accomplish the aim of drug therapy (max efficacy and min adverse effects ) you need to know

Answer 3

what drug, how much, how long, and to who

Question 4

when choosing a drug, what are the three approaches to rationalizing your decision

Answer 4

evidence based. pathophysiological and anecdotal

Question 5

changing the formulation of a drug influences

Answer 5

pharmokenetics

Question 6

what are the two major classes of drugs that are used to decrease gastric acid production

Answer 6

H2 blockers and PPIs

Question 7

what do you consider when choosing a dug

Answer 7

bioavalibility, freq of administration, efficacy, cost, labelled for use

Question 8

what are the 8 principles of pharmoacodynamics

Answer 8

1. durgs act primarily through molecular targets
2. receptor types determine response to many drugs
3. receptors can be turned on or off
4. multiple mechanisms of antagonism exsist
5. efficacy does not mean potency
6. receptors are not static
7. the body wants to maintain homeostasis

Question 9

list the four major receptor types from fastest to slowest

Answer 9

1. ligand gated ion channels
2. g protein
3. enzyme linked receptors
4. intracellular

Question 10

list the adrenoceptor impacts on the cardiovascular system

Answer 10

a1 - vasoconstriction
a2 - quick vasoconstriction to vasodilation
b1 - increase cardiac output
b2 vasodilation

Question 11

does increasing a competitive antagoism increase its effect

Answer 11

yes, since it will outcompete the endogenous compund

Question 12

what are the 3 other types of antagonism

Answer 12

physiological - agents producing opposite effects
chemical- binding of dugs
pharmacokinetic- one drug alters another