Lecture Objectives for: Autonomic Nervous System Flashcards
Neurophysiology
Ionotropic neurotransmitter
Ligand-gated ion channels to open the gate and quick, short response, turns off rapidly
Metabotropic neurotransmitter
Neurontransmitter binds to receptor and activate the G-protein, takes longer to develop but lasts longer
What are the stimulatory muscarinic receptors?
Odd M receptors (M1, M3, and M5) are stimulatory via G alpha q (increased phospholipase activity- producing IP3and DAG, increasing calcium signaling and phosphorylation)
What are the inhibitory muscarinic receptors?
Even M receptors (M2 and M4) are inhibitory via G alpha i (activates potassium channels via the G gamma beta complex and inhibits adenylyl cyclase- reducing cAMP, PKA, and phosphorylation)
G alpha s is what?
beta 1 and beta 2
What is the difference between beta-1 and beta-2?
Beta-1 is stimulatory and Beta-2 is inhibitory
G alpha i is what?
Alpha-1
What does the Alpha-1 do?
increase the concentration of Calcium and DAG (producing excitation)
G alpha q is what?
Alpha-2
What does the Alpha-2 do?
inhibits adenylyl cyclase, reduces cAMP (producing inhibition)
What’s the difference between Alpha-1 and Alpha-2?
Alpha-1 is stimulatory and Alpha-2 is inhibitory
Compare and contrast adenergic receptor mechanisms
They all bind Norepinephrine.
Gas stimulates adenyly cyclase to produce cAMP and stimulate PKA. Gaq activates phospholipase C, cleaves PIP2 to DAG and IP3, DAG activates PKC, IP3 causes the release of Ca. Gai activates G protein to either inhibits adenylyl cyclase or activates phosphodiesterases.
Sympathetic nervous system (SNS)
The ‘Fight-or-Flight’ response
Parasympathetic nervous system (PNS)
‘Rest and Digest’ response
Review the roles of the PNS and SNS in urination
Go to Week 4
