Lecture 9: Population substructure in association studies Flashcards
1
Q
Advantages of genetic association studies on unrelated people:
A
1) easy recruiltment
2) Standard met6hods for stats
3) People from former studies can be used.
2
Q
Name the three methods for dealing with population substructure in association analysis:
A
1) Genomic control
2) population substructure modelling
3) Regression based methods
3
Q
What is a null marker?
A
A marker with no functional relations to a genetic trait.
4
Q
What is the idea behind genomic control?
A
Uses empirical distributions at null loci to determine the inflation factor.
5
Q
What is an AIM?
A
ancestral informative marker
