Lecture 9

Question 1

If the rate of metabolic clearance is decreased, it may lead to

Answer 1

prolonged drug action & accumulation of toxic levels of drugs

Question 2

If the rate of metabolism increases, it may lead to

Answer 2

-decreased intensity and duration of drug action
-decreased efficacy of the drug

Question 3

what are the factors affecting metabolism?

Answer 3

1) Age differences
2)Species and Strain differences
3) Genetic Factors
4) Gender
5) Enzyme induction
6) stereochemistry of drugs

Question 4

For Genetic factors, the specific isoform of CYP450 is what?

Answer 4

CYP2D6

Question 5

Overactivity of CYP2D6 produces what?

Answer 5

higher than expected morphine concentrations in the blood due to increased conversion of codeine to morphine thru this pathway

basically codeine —-> morphine leads

Question 6

Grapefruit Juice inhibits CYP3A4 can lead to what?

Answer 6

can greatly increase duration of action of drugs primarily metabolized by CYP3A4